When metronidazole was given at random intervals after surgery, the clinical improvement was associated with a reduction in hepatic steatosis in 12 of 12 patients. In 8 patients of this group, morphology reverted to normal within the first year. In contrast, without metronidazole treatment, ...
In NAFLD mouse models, continuous administration of canertinib, an EGF receptor inhibitor, prevented the development of steatosis. Additionally, in animals with preexisting NASH, this therapy significantly reduced fibrosis.186 Other studies show a reduced number of activated hepatic stellate cells after...
In 2023, Hendriks et al. used human fetal hepatocyte organoids to model the initiation of NAFLD, specifically steatosis, triggered by free fatty acid loading, individual genetic variability, and monogenic lipid disorders [93]. This research included screening drug candidates to identify compounds effec...
In 2023, Hendriks et al. used human fetal hepatocyte organoids to model the initiation of NAFLD, specifically steatosis, triggered by free fatty acid loading, individual genetic variability, and monogenic lipid disorders [93]. This research included screening drug candidates to identify compounds effec...
HCC features were compared by FS% at MRI using logistic regression analysis and histologic steatosis grade using Cochran-Armitage test for trend, stratified by cirrhotic liver morphology or histologic fibrosis stage. Receiver operating characteristic curves were generated to determine the sensitivity and ...
However, in this study, liver steatosis was assessed by surrogate biochemical markers and not by imaging. We assessed a large group of apparently healthy individuals and is thus more likely to reflect results for the general population. Based on the ultrasonographic detection of liver steatosis, ...
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of disease severity, starting from pure steatosis, leading to fatty inflammation labeled as non-alcoholic steatohepatitis (NASH), and finally fibrosis leading to cirrhosis. Activated h
Even though our previous study observed a positive effect also on fibrosis (Gabbia et al., 2023), no studies have investigated the effect of tyrosol on NASH, a complex disease in which steatosis, low grade inflammation and fibrosis concurrently affect the liver, and on its extrahepatic ...
with its ligand has the central function in reducing liver lipogenesis, glucogenesis, and steatosis [28]. 6-Ethylchenodeoxycholic acid, a semisynthetic bile acid derivative obeticholic acid (OCA), is a powerful agonist of FXR that can decrease liver fat and fibrosis and improve hepatic steatosis ...
miR-130a regulates the hepatocyte steatosis via directly regulating PPARγ signal To confirm miR-130a could regulate the hepatocyte steatosis through PPARγ, we examined the effects of PPARγ on lipid accumulation and TG secretion in HepG2 and Huh-7 cells treated with PPARγ agonist (GW1929), ...