Table 1. Prevalence cases and deaths and age-standardized rates of cirrhosis and other chronic liver diseases by gender, by specific etiologies in China, 1990 vs. 2016 Characteristics Prevalence Mortality Number in thousands Age-standardized rate per 100,000 Number in thousands Age-standardized rate...
In parallel with the global increase in obesity, metabolism-associated fatty liver disease (MAFLD) has become the most prevalent non-communicable liver pathology9. MAFLD ranges from presymptomatic hepatic steatosis (fatty liver) to non-alcoholic steatohepatitis, which is characterized by inflammation, hep...
1 Up to one-third of patients with MASLD develop progressive steatohepatitis and fibrosis, which can lead to cirrhosis, hepatocellular carcinoma, and death.2,3 Yet, approved medications that effectively and safely reverse steatosis, inflammation, and fibrosis are lacking. Aspirin may represent a ...
Defenestration occurs prior to the development of fibrosis and has been observed in several diseases, such as hepatitis, primary biliary cirrhosis, viral infections and non-alcoholic fatty liver disease4–8. Evidence exists that the LSECs undergo the loss of the highly specialized differentiated ...
Good response to the HBV vaccine was observed in the patients with liver steatosis. 93, 7% of serocoversion to anty HB-s was observed after vaccination. The GMT of anti- HBs was 97,37 IU/l. Patients suffering from liver cirrhosis responded much less favorably to the hepatitis B vaccine ...
Progressive hepatic steatosis leads sequentially to increased intrahepatic inflammation, steatosis, fibrosis, and ultimately can result in cirrhosis and end-stage liver disease. It has been shown that inflammation and steatosis in the liver correlate with progression of coronary atherosclerosis and increase ...
30 Steatosis, lobular inflammation, and ballooned hepatocytes were classified as shown in the Supplementary Material. Fibrosis severity was scored as described previously.31 Patients with NASH-associated cirrhosis were defined clinicopathologically.32 Magnetic Resonance Elastography All of the included ...
Nonalcoholic fatty liver disease is an increasingly prevalent disorder that spans a range of conditions from hepatic steatosis to cirrhosis. It is commonly... SD Lidofsky - 《Current Diabetes Reports》 被引量: 89发表: 2008年 High-sensitivity C-reactive protein is an independent clinical feature ...
. This is similar to what we previously reported in a study of NAFLD and cirrhosis21. Fig. 2: Liver proteome remodeling due to hepatic lesions. a, Proteins in liver tissue that were significantly differentially abundant across stages of fibrosis, inflammatory activity and steatosis (FDR-corrected...
NAFLD may progress in some instances to steatohepatitis, hepatic fibrosis, and cirrhosis9 and hepatic steatosis is frequently associated with other disorders, including cardiovascular disease10, diabetes11, chronic kidney disease12, and colorectal cancer13. Like OSA, NAFLD is closely related to obesity...