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Macrophages, which are key cellular components of the liver, have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver diseases. Upon liver injury, resident Kupffer cells (KCs) sense disturbances in homeostasis, interact...
The incidence of hepatic steatosis in Chinese adults is about 15-20%. It can affect the liver function, and develops into hepatitis, fibrosis and cirrhosis of the liver. As more than 25% patients are asymptomatic or with nonspecific symptoms, a timely and correct diagnosis and treatment is ...
The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice Article Open access 23 January 2023 Molecular and cellular mechanisms of liver fibrosis and its regression Article 30 October 2020 Targeting cell death in NAFLD: mechanisms and target...
Hepatic steatosis, the accumulation of lipids in the liver, is widely believed to result in insulin resistance. To test the causal relationship between hepatic steatosis and insulin resistance, we generated mice that overexpress acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2), which catalyzes the fin...
Peroxisome proliferator-activated receptor γ (PPARγ) is induced in leptin-deficient (ob/ob) mouse liver and is critical for the development of hepatic steatosis. The present study shows that fat-specific protein 27 (Fsp27) in ob/ob liver is a direct target gene of PPARγ and can elevate...
1)Hepatic steatosis肝脂肪变 1.【Objective】The aim of this study was to determine the accord rate of the diagnosis between ultrasonography and liver biopsy on hepatic steatosis.目的探讨B超诊断肝脂肪变与肝活检的符合率。 英文短句/例句 1.Investigation of the Chronic Hepatitis B Patients with Hepatic...
steatosissteatohepatitisliver fibrosismetabolic syndromeinsulin resistanceliver biopsyBackground & AimHistologic analysis of liver biopsies allows for grading and staging of nonalcoholic fatty liver disease (NAFLD). We performed a longitudinal study to investigate the long-term prognostic relevance of ...
Conversely, hepatocyte-specific Rubicon knockout effectively inhibits HFD-induced hepatic steatosis in mice10. The involvement of defective autophagy in NAFLD suggests that augmentation of autophagy may ameliorate fatty liver disease. Usp39 (Inactive Ubiquitin-Specific Peptidase 39) is also called U4/U6....
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or “activation”) of hepatic stellate cells is the major cellular...