A compound of formula (I) or a metabolite thereof, a compound of formula (I) or an ester of a metabolite thereof, or a pharmaceutically acceptable salt thereof, respectively, is effective for the treatment of hepatic steatosis, lobular inflammation, liver hypertrophy and liver It is used to ...
Hepatic steatosis, more commonly known as fatty liver, is a condition that occurs when there is an excess amount of fat stored in the liver. There are two main types of fatty liver- alcoholic and non-alcoholic.Read more: Fatty Liver – Diet Plan, Symptoms & How to Reduce Alcoholic fatty...
Cancer is a fundamental disorder of cell proliferation that requires many cellular building blocks, such as proteins, nucleic acids, and lipids. Cancer cells alter metabolism to accumulate metabolic intermediates as sources of these building blocks [1]. The best understood metabolic change is the Warb...
10), are responsible to modulate the activity of pro-inflammatory mediators which are induced by IR, fructose- and high-fat diet-induced hepatic steatosis [100, 102, 108, 109]. It has been found that activated levels of pro-inflammatory AP-1 and NF-κB in liver are directly correlated ...
Mother nature has bestowed us with a profuse source of remedies to treat various kinds of ailments. Since time immemorial, phytochemicals, both in their natural as well as synthetic forms have been used for the treatment of various chronic diseases [12]. The root, leaf, bud, seed, bark, be...
Once LDL is trapped in the artery wall, it becomes oxidized by enzymatic and non-enzymatic processes1. The oxidation of LDL contributes to atherogenesis in many ways, including the generation of bioactive lipids that activate ECs as well as the formation of oxLDL particles that are taken up by...
Targeting the gut microbiota with resveratrol: A demonstration of novel evidence for the management of hepatic steatosis. J. Nutr. Biochem. 2020, 81, 108363. [Google Scholar] [CrossRef] Del Bo, C.; Bernardi, S.; Cherubini, A.; Porrini, M.; Gargari, G.; Hidalgo-Liberona, N.; ...
showed that all individually attenuated weight gain and macrophage infiltration into epididymal adipose tissue, while also improving glucose-insulin homeostasis and hepatic steatosis of HFD mice after 12 weeks. Overall, all three strains shifted the HFD-disrupted gut back toward that of lean mice fed ...