Thus, the hepatic environment is required to maintain a tight balance between pathogen clearance during infections and inflammatory responses, which may cause hepatocyte cell death and loss of liver function. Here, we sought to elucidate the role of LRH-1 in inflammation-driven hepatic cell death ...
Especially in case of CI-induced model, the TLR2 expression was prominent at the border edge of the wound, the area which characterized abundant expression of SAA1 and the deployment of HSCs (lower right panel in Figure S1B). This injury-induced molecular and cellular spatiotemporal appearing ...
The circle diameter covaries with pathway impact, and the fill color intensity (white to red) reflects statistical significance (decreasing p-value). The black drop with 1.3 on the y axis indicates the threshold of significance at p < 0.05. (b) Summary of MetaboAnalyst 5.0 enrichment analysis...
Dark gray dots represent cells that were negative for all the markers in the multiplex panel. (E) The same exported multicomponent TIFF files used in Figure 1D were used by the Visiopharm phenotype matrix algorithms to determine the different cellular phenotypes present in each of the 20× ...
Short-chain fatty acids in the blood may reduce oxidative stress and help maintain immune function [21]. They may also improve glucose metabolism and insulin secretion by inducing the secretion of gut hormones such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) [19]. Microbial ...
We also tested the function of SPP1 for LyECs in vitro. We found that SPP1 increased the proportion of dead LyECs significantly, and that SPP1 treatment damaged the tube formation ability of LyECs in a dose- and time-dependent manner. Taken together, our data suggested that during the ...