(Seo et al., 2009; Yoshizawa et al., 2009) by activating transcription of the metabolic hormone,FGF21(De Sousa-Coelho et al., 2012; Kilberg et al., 2009). More importantly, dietary MR produces a robust and persistent activation of transcription and release of hepatic FGF21 (Stone et al...
(PDX1)-expressing progenitor domains, a process calledspecification.43Beginning about the 23rd day of gestation, the cardiogenic mesoderm provides anFGFsignal that is important for proliferation of the precursor endodermal cells44; bothFGF1andFGF2appear to be involved.45These precursor cells ...
14]. Energy production, primarily in the form of ATP, is controlled by mitochondria that link oxidative respiration with the metabolism of nutrients, such as carbohydrates, fatty acids, and amino acids. Two major steps, oxidation of NADH or FADH2and phosphorylation...
37. To determine whether RORα also mediates PPARα transcriptional network in the liver, we examined the expression of well-known hepatic PPARα target genes, includingAcox1andFgf21. The hepatic gene expressions ofAcox1
In Crtc1 KO liver, we found that expression of Pgc1α and genes regulating the mitochondrial and peroxisomal fatty acid oxidation pathways9 upon overnight fasting was substantially reduced compared to wild-type liver (Fig. 2j). Additionally, fibroblast growth factor 21 (Fgf21), a fasting-...
In parallel, it has been shown that transcription factors such as FGF, HGF, Wnt, BMP, RA, and TGFβ to correlate with effectors influencing liver development. Therefore, it has been expected that transferring and integration, overexpression or knockdown of one or more than one transcription ...
demonstrating that the FXR agonist CDCA significantly increased FXR signaling andP. distasonisand the FXR antagonist tauro-β-muricholic acid (TβMCA) significantly decreased FXR signaling (Fig.3f).P. distasonisdecreasedFxrmRNA and the FXR target gene mRNAsFgf19andOstb, in Caco-2 cells after a ...
Results: Alcohol intervention altered the levels of 31 of 72 and 14 of 72 markers in the systemic and hepatic circulation. All changes observed in the hepatic circulation were also identified in the systemic circulation after 180 min. Only FGF21 and IL6 were increased after alcohol in...
[16]. To expand the hepatocytes, the most well-organized method is a monolayer culture of distinct cells in a step-wise manner exposure to specific cocktails of recombinant growth factors and cytokines, including Activin A, Wnt3a, HGF, OSM, FGF4, VEGF, EGF and BMP4 [184,185,186,187,...
demonstrating that the FXR agonist CDCA significantly increased FXR signaling andP. distasonisand the FXR antagonist tauro-β-muricholic acid (TβMCA) significantly decreased FXR signaling (Fig.3f).P. distasonisdecreasedFxrmRNA and the FXR target gene mRNAsFgf19andOstb, in Caco-2 cells after a ...