Heparins in ulcerative colitis: Proposed mechanisms of action and potential reasons for inconsistent clinical outcomesheparininflammatory bowel diseaselow molecular weight heparinmechanismulcerative colitisCurrent drug therapies for ulcerative colitis (UC) are not completely effective in managing moderate-to-...
Yet we restrict ourselves here to a discussion of the action of heparin on thrombin generation in platelet poor and platelet rich plasma for two reasons. In the first place it is more likely than not that inhibition of the clotting mechanism is at least one of the major working arms of ...
Heparin fractions and fragments are useful tools in the elucidation of the mechanism of action of heparin and similar substances. The identification of portions with low or high affinity for antithrombin III and of a ‘core’ pentasaccharide responsible for anti-factor Xa activity has...
With all of these limitations of UFH, low-molecular-weight heparins (LMWHs) have emerged as attractive alternatives. This review discusses the mechanism of action of LMWHs, and summarizes available literature concerning the use of LMWHs in a variety of clinical settings. Included in this review...
The additive effect of low molecular weight heparins on thrombin inhibition by dermatan sulfate. The aim of this study was to investigate the mechanism by which the anticoagulant activity of dermatan sulfate (DS) is increased by low molecular weight he......
Their mechanism of antithrombotic action is basically similar to that of UFH - to antithrombin to inhibit activated factors - but they have a different relative potency (to some extent also inter-individually) of anti-Xa versus anti-IIa activity. Shorter fragments which contain the essential to ...
They cleave the α-1,4 glycosidic linkage between acetylglucosamine and uronic acid residues through an eliminative mechanism resulting in unsaturated uronic acid residues at the non-reducing ends (Desai et al., 1993a, Desai et al., 1993b; Tripathi et al., 2012; Wu et al., 2022). ...
Sulfated fucans, frequently referred to simply as fucans, constitute a class of polysaccharides first isolated in 1913. For many years fucans were regarded... Olivier,Berteau,Barbara,... - 《Glycobiology》 被引量: 663发表: 2003年 Mechanism-based in vitro screening of potential cancer chemopreventiv...
Despite several publications on the issues related to the chemical nature of the heparin contaminants and their mechanism of action in mediating the adverse reactions, many questions related to this problem have remained unresolved. Several groups of investigators have continued to work to provide ...
Heparin and low-molecular-weight heparin. Mechanisms of action, pharmacokinetics, dosing considera- tions, monitoring, efficacy, and safety. Chest 1998; 114: 489S-510SHirsh J, Warkentin TE, Shaughnessy SG, et al. Heparin and low molecular weight heparin. Mechanism of action, pharmacokinetics,...