Heparins in ulcerative colitis: Proposed mechanisms of action and potential reasons for inconsistent clinical outcomesheparininflammatory bowel diseaselow molecular weight heparinmechanismulcerative colitisCurrent drug therapies for ulcerative colitis (UC) are not completely effective in managing moderate-to-...
With all of these limitations of UFH, low-molecular-weight heparins (LMWHs) have emerged as attractive alternatives. This review discusses the mechanism of action of LMWHs, and summarizes available literature concerning the use of LMWHs in a variety of clinical settings. Included in this review...
Prothrombin fragment F1+2, modified antithrombin, PAI and fibrinogen degradation products were not significantly effected. The association of the changes observed in these markers to the mechanism of action of LMWH or to the efficacy of the treatment, however, remains to be determined. 展开 ...
The LMWH dalteparin has been shown to decrease protracted labour in women receiving prophylaxis for deep venous thrombosis. The mechanism is believed to involve dalteparin-induced increased levels of interleukins resulting in a favourable inflammatory reaction that promotes ripening of the cervix. Further,...
Despite several publications on the issues related to the chemical nature of the heparin contaminants and their mechanism of action in mediating the adverse reactions, many questions related to this problem have remained unresolved. Several groups of investigators have continued to work to provide ...
Un- fractionated heparin, low molecular weight heparins, and pentasaccharide: ba- sic mechanism of actions, pharmacology, and clinical use. Hematol Oncol Clin North Am. 2005; 19:1-51, v.Bick RL, Frenkel EP, Walenga J, Fareed J, Hoppensteadt DA. Unfrac- tionated heparin, low molecular ...
With all of these limitations of UFH, low-molecular-weight heparins (LMWHs) have emerged as attractive alternatives. This review discusses the mechanism of action of LMWHs, and summarizes available literature concerning the use of LMWHs in a variety of clinical settings. Included in this review...
Independent claims are also included for: (1) a process for preparing (I); (2) use of avidin or streptavidin for neutralizing (I). ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. MECHANISM OF ACTION : Factor Xa inhibitor; Factor IIa inhibitor.PHILIPPE HUBERT...
Independent claims are also included for: (1) a process for preparing (Ia); (2) use of avidin or streptavidin for neutralizing (Ia). [Image] ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. MECHANISM OF ACTION : Factor Xa inhibitor....
Independent claims are also included for: (1) a process for preparing (Ia); (2) use of avidin or streptavidin for neutralizing (Ia). [Image] ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. MECHANISM OF ACTION : Factor Xa inhibitor.PHILIPPE HUBERT...