Despite several publications on the issues related to the chemical nature of the heparin contaminants and their mechanism of action in mediating the adverse reactions, many questions related to this problem have remained unresolved. Several groups of investigators have continued to work to provide ...
A comparative study on the mechanism of the anticoagulant action of mollusc and mammalian heparins. Comparative Biochemistry and Physiology , 111: 495-499.Paiva JF, Santos EA, Jeske W, Fareed J, Nader HB, Dietrich CP. A comparative study on the mechanism of the antico- agulant action of ...
With all of these limitations of UFH, low-molecular-weight heparins (LMWHs) have emerged as attractive alternatives. This review discusses the mechanism of action of LMWHs, and summarizes available literature concerning the use of LMWHs in a variety of clinical settings. Included in this review...
Drug nameProduction methodAverage Mw (Da)Half-lifea (h)Mechanism of action UFH Produced by the mast cells and blood basophils 15 000 0.5–1.5 Acting by combining to ATIII increasing its effectiveness in removing thrombin and other blood clotting factors LMWH: Enoxaparin Alkaline depolymerization of...
Their mechanism of antithrombotic action is basically similar to that of UFH - to antithrombin to inhibit activated factors - but they have a different relative potency (to some extent also inter-individually) of anti-Xa versus anti-IIa activity. Shorter fragments which contain the essential to ...
With all of these limitations of UFH, low-molecular-weight heparins (LMWHs) have emerged as attractive alternatives. This review discusses the mechanism of action of LMWHs, and summarizes available literature concerning the use of LMWHs in a variety of clinical settings. Included in this review...
Independent claims are also included for: (1) a process for preparing (Ia); (2) use of avidin or streptavidin for neutralizing (Ia). [Image] ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. MECHANISM OF ACTION : Factor Xa inhibitor.PHILIPPE HUBERT...
Independent claims are also included for: (1) a process for preparing (I); (2) use of avidin or streptavidin for neutralizing (I). ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. MECHANISM OF ACTION : Factor Xa inhibitor; Factor IIa inhibitor.PHILIPPE HUBERT...
Independent claims are also included for: (1) a process for preparing (Ia); (2) use of avidin or streptavidin for neutralizing (Ia). [Image] ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. MECHANISM OF ACTION : Factor Xa inhibitor....
Conjectures and refuta- tions on the mode of action of heparins. The limited importance of anti- factor Xa activity as a pharmaceutical mechanism and a yardstick for therapy. Haemostasis 1999; 29: 170-8.Beguin S, Welzel D, Diere RA, Hemker HC. Conjectures and refutations on th...