Despite several publications on the issues related to the chemical nature of the heparin contaminants and their mechanism of action in mediating the adverse reactions, many questions related to this problem have remained unresolved. Several groups of investigators have continued to work to provide ...
Drug nameProduction methodAverage Mw (Da)Half-lifea (h)Mechanism of action UFH Produced by the mast cells and blood basophils 15 000 0.5–1.5 Acting by combining to ATIII increasing its effectiveness in removing thrombin and other blood clotting factors LMWH: Enoxaparin Alkaline depolymerization of...
Yet we restrict ourselves here to a discussion of the action of heparin on thrombin generation in platelet poor and platelet rich plasma for two reasons. In the first place it is more likely than not that inhibition of the clotting mechanism is at least one of the major working arms of ...
Mechanism of action of heparin and heparin-like antithrombotics They may indeed replace low-molecular-weight heparins and heparinoids as the next generation of heparin antithrombotics.doi:10.1007/BF02171861Steven T. ... ST Olson,I Björk - 《Perspectives in Drug Discovery & Design》 被引量: ...
Different aspects of heparin are reviewed: different in molecular weight, bioassay, mechanism of action, clinical use and side effects. S Wessler,SN Gitel - 《Blood》 被引量: 61发表: 1979年 Prevention of Venous Thromboembolism in Cancer Using Low-Molecular-Weight Heparins Patients with cancer ar...
A comparative study on the mechanism of the anticoagulant action of mollusc and mammalian heparins. Comparative Biochemistry and Physiology , 111: 495-499.Paiva JF, Santos EA, Jeske W, Fareed J, Nader HB, Dietrich CP. A comparative study on the mechanism of the antico- agulant action of ...
With all of these limitations of UFH, low-molecular-weight heparins (LMWHs) have emerged as attractive alternatives. This review discusses the mechanism of action of LMWHs, and summarizes available literature concerning the use of LMWHs in a variety of clinical settings. Included in this review...
The additive effect of low molecular weight heparins on thrombin inhibition by dermatan sulfate. The aim of this study was to investigate the mechanism by which the anticoagulant activity of dermatan sulfate (DS) is increased by low molecular weight he......
Their mechanism of antithrombotic action is basically similar to that of UFH - to antithrombin to inhibit activated factors - but they have a different relative potency (to some extent also inter-individually) of anti-Xa versus anti-IIa activity. Shorter fragments which contain the essential to ...
Independent claims are also included for: (1) a process for preparing (Ia); (2) use of avidin or streptavidin for neutralizing (Ia). [Image] ACTIVITY : Anticoagulant; Cerebroprotective; Neuroprotective. MECHANISM OF ACTION : Factor Xa inhibitor.PHILIPPE HUBERT...