On a gravimetric basis, Bio-20 was a stronger inhibitor than Bio-6. Functional studies using the activated clotting time in whole blood and the activated partial thromboplastin time (APTT) in citrated plasma confirmed these observations. Similar results were obtained with other LMWHs such as ...
heparan sulfate proteoglycans such as perlecan, which bind to and localize bFGF, vitronectin as well as transforming growth factor-β (TGF-β), urokinase-type plasminogen activator (uPA), tissue plasminogen activator (tPA), and the serpin known as plasminogen activator inhibitor type 1 (PAI-1)....
Using this method, we were able to detect the presence of inhibitors and to monitor efficacy of inhibitor removal after treatment with heparinase. Moreover, we used the calibration curves to estimate the amount of inhibitor in particular samples by determining the dilution factor required to ...
The invention discloses an amino acid sequence of a human heparanase micromolecule polypeptide inhibitor and a group of small peptide with the binding activity of human heparanase small subunit (8kD), which belongs to the field of biomedicine. The amino acid sequence of the small peptide for ...
The invention discloses an amino acid sequence of a human heparanase micromolecule polypeptide inhibitor and a group of small peptide with the binding activity of human heparanase small subunit (8kD), which belongs to the field of biomedicine. The amino acid sequence of the small peptide for ...