HEPARIN BINDING MOTIF AND USE THEREOFA method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXX...
Identification of a Heparin-Binding Motif on Adeno-Associated Virus Type 2 Capsids 来自 国家科技图书文献中心 喜欢 0 阅读量: 109 作者:A Kern,K Schmidt,C Leder,OJ Müller,JA Kleinschmidt 摘要: Infection of cells with adeno-associated virus (AAV) type 2 (AAV-2) is mediated by binding to ...
Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion. In addition to their physiologic effects in inflammation and angiogenesis, chemokines are involved in cancer pathology. The aim of this study was to determ... A Sutton...
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In addition to the carboxy-terminal glycosaminoglycan-binding motif, we report on two novel heparin-binding domains which were identified using phage display technique. One heparin-binding domain is located between amino acids Asp82 and Cys137 at the end of the connector region, while the other ...
Identification of a heparin-binding motif on adeno-associated virus type 2 capsids. J Virol. 2003;77:11072–81. Article CAS PubMed PubMed Central Google Scholar Xie Q, Lerch TF, Meyer NL, Chapman MS. Structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (...
The PPFLMLLKGSTR motif in globular domain 3 of the human laminin-5 α3 chain is crucial for integrin α3β1 binding and cell adhesion. Exp. Cell Res. 304, 317–327 (2005). Article PubMed CAS Google Scholar Fonder, M. A. et al. Treating the chronic wound: a practical approach to...
Significance of heparin binding to basic residues in homologous to the amino terminus of hepatoma-derived growth factor and related proteins.heparinbindinghepatoma-derivedgrowthfactorPWWPmotifsurfaceplasmonresonanceHepatoma-derived growth factor (HDGF) recognizes cell surface heparan sulfate to promote its ...
Analysis of binding of 10 CTX homologues to heparin reveals a new heparin-binding structural motif by involving several positive residues at theconcave surface of the three-finger toxin (7). The positive residues flanking the three-finger loops seem to form a positive cradle for binding to long...
Similarly, this same synthetic peptide motif of HIP could block about 50% of [3H]HP binding to HIP; however, this peptide almost completely inhibited cell attachment to HIP, suggesting a critical role, in this regard. Collectively, these results suggest that HIP can function as a HP/HS-...