Heparin binding motif and use thereofA method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXX...
Infection of cells with adeno-associated virus (AAV) type 2 (AAV-2) is mediated by binding to heparan sulfate proteoglycan and can be competed by heparin. Mutational analysis of AAV-2 capsid proteins showed that a group of basic amino acids (arginines 484, 487, 585, and 588 and lysine ...
Contributions of the heparin binding motif to both the interaction with nucleolin and the biological activities of endostatin were investigated from in vitro to in vivo. Here we show that Arg to Ala point mutagenesis of the heparin binding motif does not interrupt the folding of endostatin but ...
上海玉博生物科技有限公司 主要致力于“Heparin-Binding Peptide I AG总代理 Heparin-Binding Peptide I AG Scientific.国内代理 ”的生产销售。多年的“Heparin-Binding Peptide I AG总代理 Heparin-Binding Peptide I AG Scientific.国内代理 ”生产与销售的经验,与各行
Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein Proc. Natl. Acad. Sci. U. S. A., 108 (2011), pp. 5584-5589 CrossrefGoogle Scholar 48 N. Motamedi-Shad, T. Garfagnini, A. Penco, A. Relini, F. Fogolari, A. Coraz...
As reported earlier the open conformation αX I domain binds strongly to heparin (3), but a characterization of the binding motif in heparin has not been provided. In the present study we provide a more detailed analysis of the interaction between heparin and the αX I domain and estimate ...
In addition to the carboxy-terminal glycosaminoglycan-binding motif, we report on two novel heparin-binding domains which were identified using phage display technique. One heparin-binding domain is located between amino acids Asp82 and Cys137 at the end of the connector region, while the other ...
In addition, heparin-binding epidermal growth factor (HB-EGF) weakly bound to laminins. As to the tested chemokines, C–X–C motif ligand (CXCL)-12γ bound to all laminin isoforms, whereas CXCL-11 and CXCL-12α bound weakly to laminin-332 but not to the other isoforms. Fig. 1 ...
In addition, we demonstrate the binding of heparan sulfate and dermatan sulfate to domain five. Molecular modelling of this domain reveals a conserved heparin-binding motif that we propose as the putative binding site. The fact, that different glycosaminoglycans may bind to this domain, implies ...
Identification of a heparin-binding motif on adeno-associated virus type 2 capsids. J Virol. 2003;77:11072–81. Article CAS PubMed PubMed Central Google Scholar Xie Q, Lerch TF, Meyer NL, Chapman MS. Structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (...