Compared with ATα, ATβ is preferentially located in the subendothelial layer of vascular injury site with a higher affinity to heparin and a faster rate of allosteric activation after binding to heparin, making ATβ important in maintaining systemic hemostasis [61]. In addition, lys114, lys...
This review discusses a subcategory of the adverse drug reaction, heparin-induced thrombocytopenia (HIT), known as “autoimmune HIT”, or aHIT. I define aHIT as an entity in which proximate exposure to heparin (unfractionated heparin [UFH], low-molecular-weight heparin [LMWH], or fondaparinux...
The clinical potential of LMWHs in the management of cancer-related thrombotic disorders has been recognized from the early days of the development of these agents. In the substudy analysis of various clinical trials, it has been clearly known that patients administered LMWHs exhibit a reducedmorta...
MPO activity which is response to the ischemia reperfusion injury increases in the end organ tissue sub- stantially [8]. The objective of our study is to prevent thrombus formation in the microcirculation by monitoring the effectiveness of heparin, in this way to demonstrate how much we could ...
monitored by anti-Xa activity or POCT-APTT; thus, it has not been possible to assess the effectiveness of anticoagulation based on these two assays. Fourth, heparin monitoring was often sub-therapeutic according to our targets. More data in the supra-therapeutic ranges would be required. Fifth,...