It may not be desirable for a drug intended for a specific anti-inflammatory or anti-cancer use to express a wide range of other physiological effects, such as the potentanticoagulant activityof heparin, which might lead to side-effects such as bleeding [6] and so restrict the safe dose ran...
A dose response curve relating heparin dosage to its effect on the activated coagulation time (ACT) can be determined with sufficient accuracy for clinical purposes from three ACT's. Preparation of such a curve makes it possible to maintain anticoagulation in a safe range during bypass and ...
Is Cimetidine safe for pediatric patients? Usage of Cimetidine is limited in pediatric patients. It is not recommended for patients under the age of 16 unless the physician suggests it. When prescribed to children, the dose should be adjusted depending on the patient’s weight. It should be ad...
RCA is a safe and effective anticoagulation method for CRRT in critically-ill children and it prolongs hemofilter survival. Impact RCA is superior to systemic heparin for the prolongation of circuit survival (overall and for clotting-related loss) during CRRT. These data indicate that RCA can be...
Dosage for HEP-LOCK U/P Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Slight discoloration does not alter potency. Preservative-Free Heparin Lock Flush Solution in the 100 unit/mL concentratio...
7.1 Precautions for safe handling Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam. 7.2 Conditions for safe storage, including...
These drugs have been proven to be safe and effective in multicentre clinical trials where dosage regimens have been established for prophylaxis and treatment of thrombosis. Argatroban has also been tested and approved for use in invasive cardiology procedures in the HIT patient. Dosage regimens for ...
haemofiltration using high-flux filter systems is the only way to remove an overdosage of hirudin from the circulation. In patients with renal impairment requiring hirudin treatment, it therefore seems safer to start with a low dose that is subsequently adjusted according to the activated partial ...
Healthcare-related homicidal cases are not novel within the medical–legal landscape, but investigations are often made difficult with the scarcity of material evidence related to the crime. For this reason, it is necessary to carefully analyze the clini
(23). At variance with UFH, LMWHs are mainly excreted through the kidney. Thus, repeated administration of therapeutic doses of LMWHs may lead to overdosage and/or an accumulation effect especially in patients with renal impairment, such as older individuals with a creatinine clearance (CrCl) ...