They may indeed replace low-molecular-weight heparins and heparinoids as the next generation of heparin antithrombotics.doi:10.1007/BF02171861Steven T. OlsonIngemar BjörkKluwer Academic PublishersPerspectives in Drug Discovery & DesignOlson, S. T., & Bjork, I. (1993). Mechanism of action of ...
It is now knownthat the active center serine of thrombin and other coagulation enzymesare inhibited by an arginine-reactive site on the AT Mechanism of Action Only about one third of an administered dose of heparin binds toAT, and this fraction is responsible for most of its anticoagulanteffect...
Mechanism of the anticoagulant action of heparin. Molecular and Cellular Biochemistry 1982;48(3): 161–82. [PUBMED: 6757715] Bruschettini 2015 Bruschettini M, Romantsik O, Zappettini S, Banzi R, Ramenghi LA, Calevo MG. Antithrombin for the prevention of intraventricular hemorrhage in very ...
In addition to heparin, PF4 can form complexes with other anions such as bacterial LPS andnucleic acids. Recently, it has been proposed that HIT may be a misdirected antibacterial immune mechanism in which the rapid generation of IgG antibodies that serve to rapidly clear bacteria coated with PF4...
They are, however, very diverse, generally being from different protein families and generally having very different structures, cells of origin, sequences, and patterns of expression, as well as having remarkably distinct modes of action and function. They frequently contain many integrin binding ...
Epidermal growth factor receptor (EGFR) has been implicated in tumour growth and extension of ovarian cancer. Peritoneal fluid in ovarian cancer patients contains various growth factors that can promote tumour growth and extension. In order to investigat
- 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 191发表: 1998年 Mass spectrometric evidence for the enzymatic mechanism of the depolymerization of heparin-like glycosaminoglycans by heparinase II Heparin-like glycosaminoglycans, acidic complex polysaccharides ...
Context: Ximelagatran, an oral direct thrombin inhibitor with a rapid onset of action and predictable antithrombotic effect, has the potential to be a simple therapeutic alternative to current standard treatment of acute venous thromboembolism. Objective: To compare the efficacy and safety of ximelagatran...
Interestingly, ultra-low-molecular-weight heparin was also effective in the treatment of late airway responses (pre- or post-antigen challenge); the effect was independent of the anticoagulant activity of the heparin and was mediated by an unknown biological action (Molinari et al., 1998, Ahmed ...
Rosenberg, R.D. and Damus, P.S.: The purification and mechanism of action of human antithrombin-heparin cofactor. Journal of Biological Chemistry 248: 6490–6505 (1973). PubMedCASGoogle Scholar Salzman, E.W.; Deykin, D.; Shapiro, R.M. and Rosenberg, R.: Management of heparin therapy....