Olson, S.T.; Bjork, I. Mechanism of action of heparin and heparin-like antithrombotics. Perspect. Drug Discov. Des. 1994, 1, 479-501. [CrossRef]Olson ST, Bjo¨rk I (1993) Mechanism of action of heparin and heparin-like antithrombotics. Perspect Drug Discov Des 1:479-501...
肝素的抗凝作用,依赖于抗凝血酶III(AT III)。肝素的抗凝机制(Mechanism of action) 激活的AT III是凝血酶(FIIa)及FⅫa、FⅪa、FⅨa、FXa等含丝氨酸的蛋白酶的抑制剂。 肝素与AT的结合位点:五糖序列(Pentasaccharide)(戊糖) 肝素聚合物中包含的特定五糖硫酸化序列(pentasaccharide sulfation sequence) ,即GlcNA...
Mechanism of Action Only about one third of an administered dose of heparin binds toAT, and this fraction is responsible for most of its anticoagulanteffect.11, 12 The remaining two thirds has minimalanticoagulant activity at therapeutic concentrations, but atconcentrations greater than usually obtained...
Mechanism of Action Once administered, heparin binds to several proteins; however, it is binding to an antithrombin that is important, as this causes a surface change and inactivates thrombin. Binding to antithrombin blocks several different factors of the clotting cascade, but two are predominant: ...
Mechanism Of Action Heparin interacts with the naturally occurring plasma protein, Antithrombin III, to induce a conformational change, which markedly enhances theserineproteaseactivity of Antithrombin III, thereby inhibiting the activated coagulation factors involved in the clotting sequence, particularly Xa ...
Mechanism of action The anticoagulation action of heparin depends on the presence of a specific serine protease inhibitor (serpin) of thrombin, antithrombin III, in normal blood. Heparin binds to antithrombin III and induces a conformational change that accelerates the interaction of antithrombin III wi...
Investigating the mechanism of action of "low dose heparin" it could be shown that this type of anticoagulation--in addition to other mechanisms--inhibits the contact phase of the intrinsic coagulation system. Thus "low dose heparin" would be directed against the hypercoagulability that arises via...
12.1 Mechanism of Action Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of heparin in combination with antithrombin III (heparin cofactor) ca...
Mechanism of action The anticoagulation action of heparin depends on the presence of a specific serine protease inhibitor (serpin) of thrombin, antithrombin III, in normal blood. Heparin binds to antithrombin III and induces a conformational change that accelerates the interaction of antithrombin III wi...
The anticoagulant properties of the glycosaminoglycan heparin have made it an invaluable drug for the prophylaxis and treatment of thrombosis. These proper... ST Olson,I Björk - 《Perspectives in Drug Discovery & Design》 被引量: 24发表: 1994年 Mechanism of action of heparin and heparin-like...