Hobbelem PMJ, Van Dinther TG, Vogel GMT, Van Boeckel CAA, Moelker HCT, Meuleman DG: Pharmacological profile of the chemically synthesized antithrombin 111 binding fragment of heparin (pentasaccharide) in rats. Thromb Haemost 63:265, 1990
Moreover, a systemic treatment would not be expected to interfere with the action of antibodies against SARS-CoV-2 because the MD simulations show that heparin does not interact with the main regions targeted by antispike antibodies (33): it does not shield either the RBm or the RBD ...
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(Fig.7A and B). Thus, substrate coating has an impact on FN fibrillogenesis, consistent with previous reports51,52. The fact that FN fibrillogenesis was impaired on FN-Glut prompted us to investigate whether pharmacological inhibition of fibrillogenesis leads to loss of directional persistence ...
Figure 2. The anti-inflammatory, anti-microbial, and mucoactive pharmacological properties of heparin and its derivatives are proposed to reduce mucus obstruction of the inflamed airways, and the cycles of infection and inflammation that lead to tissue damage. NETs; neutrophil extracellular traps. HSPG...
Pharmacological and clinical differences between low-molecular-weight heparins: Implications for prescribing practice and therapeutic interchange. Pharm. Ther. 2010, 35, 95–105. [Google Scholar] Hachim, D.; Whittaker, T.E.; Kim, H.; Stevens, M.M. Glycosaminoglycan-based biomaterials for growth ...
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