Unfractionated heparin infusion therapy is often administered using a weight- based dosing strategy for the treatment of venous thromboembolism. In the last several decades, the prevalence of obesity in the United States has increased significantly.Is...
Heparin therapy improves clinical outcomes in patients with thromboembolic disorders [1-4], but the determination of appropriate heparin dosing is often problematic. Physicians' dosing decisions vary widely, as do their therapeutic goals [5]. Practice audits reveal frequent underdosing, with delays in...
The therapeutic range for anti-factor Xa activity depends on the dosing interval. Anti-factor Xa monitoring is prudent when administering weight-based doses of LMWH to patients who weigh > 150 kg. It has been determined that UFH infusion is preferable to LMWH injection in patients with ...
The weight-based heparin dosing nomogram compared with a "standard care" nomogram. Ann Intern Med. 1993;119874- 881Google ScholarCrossref 30. Hull RDRaskob GERosenbloom D et al. Optimal therapeutic level of heparin therapy in patients with venous thrombosis. Arch Intern Med. 1992;1521589- ...
(15 IU/kg/h) without adaptation to body weight, renal function, or CRP. Bottom panels: simulations according to our optimized dosing regimen. Bottom left panel: 4000 IU loading dose followed by a 1500 IU/h maintenance dose. Bottom right panel: 8000 IU loading dose followed by a 1500 IU/...
Poisik and colleagues38recently reported their results using weight-based dosing of heparin at 85 U/kg. Although they did not see any statistically significant differences between fixed-doseheparinization(5000 U) and weight-based dosing, there were trends of decreased complications of hematoma formatio...
There are no adequate and well-controlled studies on heparin use in pediatric patients. Pediatric dosing recommendations are based on clinical experience [seeDOSAGE AND ADMINISTRATION]. Geriatric Use There are limited adequate and well-controlled studies in patients 65 years and older. However, a high...
5,000 Units by intravenous injection Continuous 20,000 to 40,000 Units every 24 hours in 1,000 mL of 5% Dextrose Injection 2.4 Pediatric Use There are no adequate and well-controlled studies on heparin use in pediatric patients. Pediatric dosing recommendations are based on clinical experience...
Heparin and Low-Molecular- Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety Jack Hirsh, MD, FCCP, Chair; Theodore E. Warkentin, MD; Stephen G. Shaughnessy, PhD; Sonia S. Anand, MD; Jonathan L. Halperin, MD; Robert Raschke, MD, MS; Christopher...
Evaluation of a Weight‐Based Heparin Dosing Protocol Aim: To describe the anticoagulant effect, as assessed by initial activated partial thromboplastin time (APTT) result and time taken to reach the target AP... SA Slader,SA Welch,A Finckh,... - 《Journal of Pharmacy Practice & Research》 ...