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The argatroban dosage for this patient exceeded the upper limit of the dose range for adults. Several possible explanations for why argatroban did not illustrate typical first-order pharmacokinetics in this patient are discussed, and the pharmacokinetics and pharmacodynamics of argatroban are compared ...
Platelet-poor plasma was prepared by centrifugation at 3000 x g for 20 min at 4T and stored at -70°C in polypropylene 405 406 SCHMIDT ET AL tubes until assayed. Plasmas of healthy and orally anticoagulated adults were pooled to obtain normal and abnormal adult plas- mas, respectively. ...
When heparin levels are below the target range for a patient, the result may be worsening clot formation, with potential for embolic organ failure or embolic stroke and death. Should heparin levels exceed the target range, major bleeding may occur, potentially triggering hemorr...
Background: Low molecular weight heparin (LMWH) is used for the treatment and prevention of coagulative disorders. Few patients receiving therapeutic doses of LMWH develop major hemorrhage. Currently there are few reports in the literature on acute overdose on adults. In this study, clinical ...
Data regarding clinical management and heparin dosage were collected.#Fifty patients, including 42% postcardiotomy, were included between April 2020 and May 2021, with a total of 447 samples. Median extracorporeal membrane oxygenation duration was 7 (interquartile range, 4 to 12) days. Median ...
Target-range antifactor Xa levels were achieved with the new protocol in 122 (87%) of 140 patients within 24 hours of start of therapy.Conclusion. A UFH dosage protocol based on patient sex, age, height, and weight produced improved initial target antifactor Xa levels compared with a weight...
However, there is an urgent need to search for new therapeutic biomarkers and develop targeted therapeutic strategies that can expand the range of therapeutic options currently available [23]. The use of heparin and low-molecular-weight heparin (LMWH) in the treatment of cancer has recently begun...
The average BMI of the sample was 28.81 kg/m2, which is considered overweight. It is noteworthy that 42.5% of the sample was in the obese range (>30 kg/m2), a result that differs greatly from the prevalence (17.4%) of obesity in Spain [35] for the population over 18 years. However...