Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricu- lar dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Am Heart J 2012; 163: 33-...
38 Animmediate anticoagulant effect requires an IV bolus. In the circulation, heparin binds to a number of plasma proteins (Fig 5), which reduces its anticoagulant activity at low concentrations, thereby contributing to the variability of the anticoagulant Laboratory Monitoring Randomized trials show a...
Dosing recommendations vary for each indication. Most heparin drips will be initiated with a bolus injection of 80 units/kilogram intravenously, followed by a continuous infusion rate of 18 units/kilogram/hour. In obese populations, these dosages are capped off at a maximum bolus infusion and ma...
We describe a 388-kg man who was started on an intravenous infusion of heparin according to hospital protocol for suspected pulmonary embolism. The patient was given a 5000-unit heparin bolus followed by an initial heparin infusion rate of 1500 units/hour, the maximum initial rate specified in...
bolus and a continuous intravenous infusion of placebo throughout initial therapy. to maintain double-blinding, aptts were reported only to a member of the health care team not involved in assessing the patient's outcome. the aptt was not recorded on the patient's medical chart during the ...
There are three distinct syndromes of heparin-inducedthrombocytopenia: an acute reversible form seen immediately after intravenous bolus injection, a delay... C Cola,J Ansell - 《American Heart Journal》 被引量: 94发表: 1990年 Combination antiangiogenesis therapy with marimastat, captopril and fragmin...
DVT & PE Prophylaxis 5000 units SC q8-12hr, OR 7500 units SC q12hr Treatment 80 units/kg IV bolus, THEN continuous infusion of 18 units/kg/hr, OR 5000 units IV bolus, THEN continuous infusion of 1300 units/hr, OR 250 units/kg (alternatively, 17,500 units) SC, THEN 250 units/kg...
We describe a 388-kg man who was started on an intravenous infusion of heparin according to hospital protocol for suspected pulmonary embolism. The patient was given a 5000-unit heparin bolus followed by an initial heparin infusion rate of 1500 units/hour, the maximum initial rate specified in...
We describe a 388-kg man who was started on an intravenous infusion of heparin according to hospital protocol for suspected pulmonary embolism. The patient was given a 5000-unit heparin bolus followed by an initial heparin infusion rate of 1500 units/hour, the maximum initial rate specified in...
bolus of lipopolysaccharide and 10 mins later unfractionated heparin, low-molecular-weight heparin, or placebo as bolus primed continuous infusion for 6 hrs.MEASUREMENTS AND MAIN RESULTSLipopolysaccharide infusion induced similar increases of tumor necrosis factor-伪, interleukin-6, interleukin-8, C-...