Reliable objective approaches for the detection and characterization of sleep problems may turn out to be relevant for clinical screening of sleep. The values from the commercially available actigraphy processing software have usually been developed in healthy subjects with regular sleep patterns and are ...
Future studies of drug effects on cultured tumor cells should include a metabolomic component in order to understand the effect of the drugs on intermediary metabolism, especially if such studies are part of a high-throughput screening protocol within the drug discovery and development process [31,...
New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 1990, 82, 1107–1112. [CrossRef] 23. DeLean, A.; Munson, P.J.; Rodbard, D. Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-...
The C-21 angeloyl group and C-22 ovaleric group, as well as the combination of aglycone and sugar moieties make oleiferasaponin A2 without cytotoxic activity. The results of preliminary screening of hypolipidemic activity demonstrated that 10 µM oleiferasaponin A2 (p = 0.027) and 10 µM ...
International Journal of Molecular Sciences Article Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway Xing-Xian Guo 1, Xiao-Peng Li 1, Peng Zhou 1, Dan-Yang Li 1, Xiao-Ting Lyu 1, Yi Chen 1, Yan-Wei Lyu 1, Kuan Tian 2, De-Zhi Yuan 2, ...
Some levopimaric derivatives act against respiratory viruses, the papilloma virus, and the hepatitis B and C viruses [22] (Figure S1). Notably, our research has indicated that the urushiol derivatives have a remarkable binding affinity with good scoring of histone deacetylase (HDAC)2 and HDAC8 ...