These structures feature a hydrophobic core that solubilizes drugs and a hydrophilic shell that protects them from degradation and interaction with blood components. Among the various micellar formulations, those made with Soluplus and D-α-tocopheryl polyethylene glycol succinate (TPGS) are particularly ...
Effect of normoxia/hypoxia and melatonin treatments on VEGF mRNA levels (B), VEGF cell protein levels (C) and VEGF secreted to the culture media (D). HUVECs tube formation assay (E). Tube formation index (S.CORE) (F). Data are expressed as a percentage of mean values±s.e.m. of ...
A, B The non-linear regression analyses were performed to estimate the half-maximal inhibitory concentrations (IC50) of EVO/HP-β-CD and evodiamine. C Cell proliferation inhibition of presented concentrations of evodiamine, EVO/HP-β-CD (0.1–100 μM) and HP-β-CD (1.3 mM) was evaluated ...
The domains of TG2-S (in blue) are the core domain (central circle), the N-terminal domain (oval shape) and the C-terminal domain (rectangular shape). The aggresome is depicted in purple. TG2 is also involved in the homeostasis of the actin cytoskeleton, the regulation of which is ...
BDE-47 was also positively associated with the KRAS signaling and negatively with the reactive oxygen species pathway, UV response UP, and allograft rejection. Figure 3. Heatmaps of combined DEGs and DEPs associated with the significantly enriched Hallmark gene sets (a) mTORC1 signaling, (b) ...
(encapsulated) or covalently attached pro-drugs to the PAMAM core. There is a variety of PAMAM terminal amine group modifications reported till now, like PEG-ylation, acylation, and hydroxyalkylation [3,4,5,6,7,8,9,10,11,12], which modify not only the basicity of intrinsic nitrogen ...
2.11. Intracellular ROS Level Measurement Intracellular ROS production was measured using dihydroethidine (DHE) dye (Assay Kit Reactive Oxygen Species (ab236206), Abcam, Cambridge, UK) in live cells, which is selective for superoxide anion and hydrogen peroxide. Briefly, following incubation with ...
Cardiotrophin-1 has been shown to have protective properties against reactive oxygen species produced during ischemia of non-steatotic pig livers [6]. Surgical ischemic preconditioning, which involves brief clamping of blood vessels followed by reperfusion, prior to removing the organ from the donor ...
isolated from ~106 HepG2 cells treated with vehicle, E2, PPT, or DPN using RNeasy Mini Kits (Qiagen, Foster City, CA, USA), was conducted at the University of Cincinnati Ge- nomics, Epigenomics, and Sequencing core facility, according to the standardized protocols that were developed by th...