In HistoryExamples of the transmission of hemophilia have been found in several royal families. The family of Queen Victoria of England and, later, that of her granddaughter the Czarina Alexandra Feodorovna were affected. The apparent ability of Rasputin to check the hemophilia of the czarina's ...
1,3,7,16 Contrariwise, certain bleeders who suffer only from easy bruising or excessive postoperative bleeding, often without a family history of a hemorrhagic tendency, prove to have hemophilia after determination of plasma AHF.5,11 These observations have led to the recognition of hemophilia as...
Brad Dell, Director of Community Content Brad graduated from the University of Hawaii at Manoa in 2016 with a double major in history and journalism. He previously worked as a copy editor for Nella Media Group, managing editor for Ka Leo O Hawaii, and executive editor for Abstract Magazine....
History, labor... BA Parra,ZNA Valencia,BDA Espinal,... - 《Revista Chilena De Pediatría》 被引量: 1发表: 2015年 PCR and Cancer Diagnostics: Detection and Characterization of Single Point Mutations in Oncogenes and Antioncogenes The theory that the accumulation in a single cell of genetic...
HistoryThe World Federation of Hemophilia (WFH) states in its Guidelines for the Management of Hemophilia, Second Edition [1], that people with hemophilia are best managed in a comprehensive care setting. That team is typically comprised of a core group including a hematologist, nurse coordinator...
A history of clinically significant surgery without therapy and without excessive bleeding strongly suggests, but does not guarantee, satisfactory hemostasis with subsequent surgery. In the United States, patients with factor XI deficiency should be given plasma products before surgery when their risk is...
BioMarin Pharmaceutical Inc. (Nasdaq: BMRN) today announced that an individual in Germany with severe hemophilia A was treated with ROCTAVIAN® (valoctocogene roxaparvovec-rvox), marking the first time that the gene therapy has been...
Certainly, we see patients who have classic <1% factor levels, yet present with a milder-than-expected bleeding history. These patients are difficult to persuade to take regular doses of factor because they feel it will not significantl...
To date, none of the subjects enrolled in the hemophilia trials developed antitransgene antibodies, despite the fact some of them were carriers of null mutations in the FIX gene.6,11,23,25,26,91 It should be noted, however, that all subjects who had a history of anti-FIX antibody ...
Although the mechanism underlying tolerance induction is incompletely understood in hemophilia, we have increasingly been able to identify factors associated with increased inhibitor development including large gene deletions, family history, race/ethnicity, age, and intensity of first exposure to factor and...