clinical sign to be “blood in the urine.” In true hemoglobinuria, without hematuria, microscopic examination will reveal the absence of red blood cells (RBCs). Distinguishing hemoglobinuria from hematuria is an important diagnostic consideration. Conventional urine test strips (dipsticks) do not diff...
cells lacking expressionmonocytemultiparameter flow cytometryneutrophilparoxysmal nocturnal hemoglobinuriared blood cell high‐sensitivity detectionwhite blood cell high‐sensitivity detectionAndrea IllingworthMichael KeeneyD. Robert SutherlandJohn Wiley & Sons, Ltd...
However, patients who had a thrombotic event displayed greater median LDH levels (7.2 ± 6.1 versus 4.6 ± 3.1 folds over ULN, mean ± SD), and median clone size (73.5 ± 26 versus 59.8 ± 23% of GPI negative cells, mean ± SD) than cases without ...
Quantitative proteome profiling identifies the response to unfolded proteins as a potential damage pathway in heme-exposed HK-2 cells. We incubated SILAC-labeled HK-2 cells with or without heme (10 and 40 μM) for 8 h and defined heme-triggered proteome changes by LC-MS/MS. In six ...
The red blood cells showed moderate aniso-and poikilocytosis, and occasional nucleated red cells were visible. The white blood cell count was 4000/mm3 with 31 per cent neutrophils, 25 per cent bands, 2 per cent metamyelocytes, 4 per cent myeloblasts, 24 per cent 展开 ...
Paroxysmal cold hemoglobinuria is a syndrome characterized by the intravascular hemolysis of red blood cells and the excretion of hemoglobin in the urine following exposure to cold. It is one of the rarer complications of late syphilis. ... FT Nichols,CJ Williams - 《Journal of the American Medi...
It has been postulated that accumulation of C3b on the surface of the red cell due to C5 blockade may cause increased extravascular red blood cell clearance by the spleen and liver.73 However, a recent report suggests that although patients may have increased C3b on their red blood cells, ...
Long standing eculizumab treatment without anticoagulant therapy in high-risk thrombogenic paroxysmal nocturnal hemoglobinuria Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-orphan disease affecting all hematopoietic cell types. The abnormality of red blood cells in this dis... HA Al-Jafar,AlDallal...
B. The dual pathophysiology theory: PIG-A gene mutation may occur without provoking the PNH disease.To induce the clonal expansion necessary for developing clinical PNH,additional factors should occur,which create conditions permissive to expansion of mutated cells. Such extrinsic factors are postulated...
Blood 1984; 64: 847–851. Rosti V, Tremml G, Soarez V, Pandolfi PP, Luzzatto L, Bessler M. Mu-fine embryonic stem cells without PIG-A gene activity are competent for PNH-like hematopoiesis but not for clonal expansion. J Clin Invest 1997; 100: 1028–1036. CrossRef Rotoli B, Lu...