However, at higher heme concentrations (20 and 40 μM), we observed a cytotoxic response with the irreversible breakdown of the epithelial barrier. Similar to our previous studies in HMOX1 knockout cells, we found that the toxic heme exposure of HK-2 renal epithelial cells caused oxidative ...
If you have aHUS, your doctor will need to monitor you closely for at least 12 months after stopping treatment for signs of worsening aHUS or problems related to a type of abnormal clotting and breakdown of your red blood cells called thrombotic microangiopathy (TMA). Symptoms ...