We report a case of 19 years old female with PNH presenting with renal failure due to renal hemosiderosis.Key words: hemosiderosis,hemolysis, Paroxysmal nocturnal hemoglobinuria, renal failureJyoti SharmaSunita SinghAshok SangwaiyaSonia HasijaSwati Sharma...
The resultant loss of complement inhibition produces chronic complement-mediated hemolysis of PNH cells. This chronic state of hemolysis can be exacerbated if the complement system is activated by stress due to surgery, trauma, or other triggers for inflammation. û收藏 转发 评论 ñ赞 ...
Background / Purpose: While many patients with paroxysmal nocturnal hemoglobinuria (PNH) have anemia, low hemoglobin levels and transfusion requirements may not adequately reflect the burden of disease due to hemolysis since these para... Y Kanakura,S Okamoto,K Ohyashiki,... - Congress of the ...
The management of the patient depends on whether anemia is due to hemolysis or as consequence of impaired erythropoiesis. Corticosteroids at a dose of 0.25-1 mg/kg/day was selected as it is amongst the various treatment options in patients with predominant hemolysis. 展开 关键词:...
Introduction Paroxysmal nocturnal hemoglobinuria is an acquired disorder of hemopoiesis and is characterized by recurrent episodes of intravascular hemolysis due to an increased sensitivity to complement-mediated hemolysis. Systemic lupus erythematosus with paroxysmal nocturnal hemoglobinuria is very rare. We repo...
A 73-year-old female who had been diagnosed with PNH in 1987 and responded to low-dose steroid therapy was admitted to our hospital in June 1993 because of ARF caused by severe intravascular hemolysis. On admission, she had high levels of serum LDH (7, 320IU/l), BUN (130mg/dl) and...
However, I have been unable to find a case reported in the English literature. In view of the rarity of the condition and the interesting phenomena which are associated with the mechanism of hemolysis, the case which I shall report is of more than ordinary interest. 展开 ...
Hemoglobinuriacommonly occurs in association with the vena cava syndrome (i.e., acute hemolytic crisis caused by obstruction of the vena cava with adult worms) and occasionally when severe pulmonary arterial disease results in fragmentation hemolysis due to fibrin-thrombus formation. Thrombocytopenia is ...
An acquired hemolytic disease, due to proliferation of an abnormal clone(s) of myeloid stem cells, the progeny of which are susceptible to complement-mediated membrane damage and hemolysis–CMH Clinical Thromboses, ↑ infections; PNH may evolve into aplastic or sideroblastic anemia, myelofibrosis, AML...
In 1888, Stribling recognized that the hemolysis was due to a problem within the red blood cell.2 This was confirmed by Van de Burgh who noted that the hemolysis was not related to the "cold" or the Donath Landsteiner reaction.3 Crosby et al noted the association of bone marrow failure...