However, target cells are much more numerous in Hb CC disease than in mild thalassemia, and the presence of C crystals will establish the diagnosis. SC disease can also be confused with Hb CC disease. However, the crystals in SC disease are usually not straight or well formed, and the ...
These results may be significant in understanding SC disease.doi:10.1182/blood.V74.5.1823.1823Margaret J. LinRonald L. NagelRhoda Elison HirschBloodLin, M. J., Nagel, R. L., Hirsch, R. E. (1989) The acceleration of hemoglobin C crystallization by hemoglobin S. Blood 74: pp. 1823-1825...
Intraerythrocytic hemoglobin crystals in sickle cell-hemoglobin C disease. Blood 1965;25:218 A/223.Diggs LaB, A (1965) Intraerythrocytic hemoglobin crystals... LW Diggs,A Bell - 《Blood》 被引量: 39发表: 1965年 Dyserythropoiesis, Sideroblasts/Siderocytes and Hemoglobin Crystallization in a Dog...
Hemoglobin C is mainly of clinical significance when inherited in combination with Hb S (Hb SC disease), or when co-inherited with β-thalassemia (hemoglobin C–β thalassemia). Little data exist regarding individuals who have very rare genotypes (eg, hemoglobin C–hemoglobin E compound heterozygot...
Keywords: Hemoglobinopathies; Thalassemias; Sickle cell disease; Management; Prevention The inherited hemoglobin disorders are the most common single gene defect in man. The frequency of the carrier state has been estimated to be 270/million with about 400,000 annual births a year of infants with...
(b6 Glu-Lys) in Western Africa Cigar-like crystals Billiard ball cells Folded cells Hb SC disease Washington monument cells Mitten shape Hb E (b26 Glu-Lys) in SEA Moves with Hb A2 in Hb ELP and A2 column (ie, false elevated Hb A2) Hb SC disease Hb C disease Unusual Hemoglobins in...
Hemoglobin C diseaseThe typical rod-shaped HbC crystals in the peripheral blood smear often provide the diagnostic clue to the HbC disease. This case highlights that a careful review of blood film morphology may be helpful to detect HbC disease, although this case's routine blood test is normal...
() Citation Context ...and the sickle-cell gene (SC). The former case leads to hemoglobin C disease, which is a mild form of anaemia. The physical mechanisms of crystallization of hemoglobin C have been intensively studied =-=[48,49,50]-=-. Secondly, mutations in the γ-crystallin ...
Chemical heterogeneity of fetal hemoglobin in subjects with sickle cell anemia, homozygous Hb-C disease, SC disease, and various combinations of hemoglobin variants. This study has determined the ratio of G γ to A γ chains in the fetal hemoglobin of individuals with various combinations of abnorm...
However, the crystals in SC disease are usually not straight or well formed, and the irregular spiked or hooked cells of SC disease are not a feature of CC disease. A more pronounced microcytosis than expected and an elevated HbA2 would support a diagnosis of C/β-thalassemia. A variable ...