hemoglobin affinity for oxygenlipid peroxidationpyrogenalfeverMajor parameters of oxygen transport and lipid peroxidation are measured in the blood of rabbits with fever, and it is found that hemoglobin affinity for oxygen is decreased while free-radical processes are activated in this state. The data...
The effect of altered hemoglobin-oxygen affinity on oxygen transport by hemoglobin solution Oxygen dynamics were evaluated in eight baboons following total exchange transfusion with either stripped (SFH) or pyridoxylated (SFH-P) stroma-free hemogl... SA Gould,A Rosen,L Sehgal,... - 《Journal ...
The long-term, genetically coded adaptations in oxygen transport encountered in animals that permanently are subjected to low environmental O2 tensions commonly result from changes in the molecular structure of Hb, notably amino acid exchanges that alter Hb's intrinsic O2 affinity or its sensitivity ...
The transport of oxygen to peripheral tissues is regulated by several factors, includingblood oxygencapacity, cardiac output, and hemoglobin-oxygen affinity. (1) Oxygen capacity is a direct function ofhemoglobin concentration(1 g hemoglobin combines with 1.34 mL oxygen). (2) Compensatory changes in ...
Hemoglobin can be considered to exist in active and inactive states. When the iron atom is in the ferrous form, the protein is active and can bind oxygen reversibly; high and low affinity substates account for the cooperativity of ligand binding. However, like bulk metal, the iron can rust....
However, on going from 20°C to 37°C, the difference in O 2 affinity between the two hemoglobins is restored, as it should if oxygen has to be transferred from maternal to fetal blood, by virtue of the lower overall heat of oxygenation (Δ H ) displayed by fetal Hb when in the ...
HbF differs most from adult hemoglobin (HbA) in that it is able to bind oxygen with greater affinity than HbA, giving the developing fetus better access to oxygen from the maternal bloodstream. When fetal hemoglobin production is switched off after birth, normal children begin producing HbA. ...
The model mainly focuses on low capillary hematocrits and studies the effect of free hemoglobin affinity, cooperativity and concentration. The results are expressed in the form of cell and capillary mass transfer coefficients, or inverse transport resistances, that relate the spatially averaged flux of...
Oxygen affinity of hemoglobin and red cell 2,3-diphosphoglycerate in hepatic cirrhosis. The level of 2,3-diphosphoglycerate (2,3-DPG) in erythrocytes was found to be increased in patients with cirrhosis of the liver, and as a consequence the o... J Astrup,M Rorth - 《Scandinavian Journal...
Free hemoglobin in solution has some of the properties required for such preparations, but it also suffers from three major drawbacks: short vascular half-life, high oxygen affinity, difficult to store. This paper summarizes the experimentations described in literature and reports the main results ...