Its mechanism of action in this field involves its ability to bind to heme groups and facilitate the study of their structure and function. Medical Research: Hemin has been used in medical research for its potential therapeutic applications. It has been studied for its anti-inflammatory, ...
The mechanism of action of trioxane antimalarial drugs is still largely controversial and warrants further investigation. We report here on the direct reaction of artemisinin with hemin, carried out in DMSO, in the absence of reducing agents. The reaction was analysed, independently, by visible ...
But the mechanism of formation of membrane topologic defects which finally leads to the changes of cell shape and deformability is currently unclear. The hemin is a substance which alters the morphology of cells. The objects of its action in RBC are known. The optical microscopy and electron ...
Bottom: Mechanism of C60-doped supported BLM [7,34]. Show moreView chapter Chapter Globins and Other Nitric Oxide-Reactive Proteins, Part B Methods in Enzymology Book series2008, Methods in Enzymology Marie‐Alda Gilles‐Gonzalez, ... Jason Tuckerman Explore book 2.2.2 Quality control Heme cont...
These results indicated that artesunate might undergo the identical antimalarial mechanism as its parent compound Qinghaosu, and hemin plays a catalyst role in the process of action of Qinghaosu-type antimalarial drugs. 展开 关键词: Medicine
Isolation of an outer membrane hemin-binding protein of Haemophilus influenzae type b. Haemophilus influenzae is a heme-dependent bacterium. However, little is known of the heme-iron uptake mechanism in this organism. By using a batch ligand affinity chromatography method, a hemin-binding protein of...
This indicates that hemin alters the mechanism responsible for allowing cell migration, which may account for the decrease in the migratory capacity of hemin-treated LM3 cells. As Ridley et al. have previously described, the family of Rho-GTPases are the main proteins responsible for the ...
The second generation of HO-1 inhibitors, with the first imidazole-based compound being Azalanstat (or QC-1) [232], has been growing in the last decade as several new compounds have been synthesized starting from compounds QC-13 and QC-308 [233,234]. The proposed mechanism of action of ...
The objective of this study was to investigate the protective effect and potential mechanism of action of hemin on bleomycin-induced pulmonary fibrosis in mice. Male C57BL/6 mice were randomly divided into control, bleomycin and bleomycin hemin groups. Mice in the bleomycin...
16, 17, 18, 19 This clustering was ascribed to binding of HCRs to band 3.20 Another possible mechanism of membrane damage may involve liberation of hemin and/or iron from the Hb degradation products.21, 22 In our previous communication, we have demonstrated that Hb exerts a marked ...