It has been shown that p50: p50 homodimers decrease the transcriptional activity of pro-inflammatory genes and stimulate the transcription of IL-10, whereas the expression of the heterodimer p65: p50 in response to LPS in peripheral blood mononuclear cells (PBMCs) of subjects with sepsis is ...
An obvious difference in environmental conditions for blood/cat flea vs. feces is the presence of heme, a metabolite with concentrations that can go up to toxic levels—about 5mM in the arthropod vector after a blood meal [130,131]. B. henselae expresses hemin-binding protein C to protect ...
The main outcomes will be a change in cognitive testing results, in level of inflammatory markers in blood, and in the amount of brain amyloid protein. This study is ongoing, but is not recruiting participants. Additionally, a randomized, double-blind, placebo-controlled phase 2 study (NCT...