Hematopoietic stem cell development: an epigenetic journey. Curr Top Dev Biol. 2014;107:39–75.Cullen S.M., et al., Hematopoietic Stem Cell Development: An Epigenetic Journey. Stem Cells in Devel- opment and Disease, 2014. 107: p. 39-75....
This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The...
During development, hematopoietic stem cells (HSCs) emerge in the aorta-gonad-mesonephros (AGM) region through a process of multi-step maturation and expansion. While proliferation of adult HSCs is implicated in the balance between self-renewal and differentiation, very little is known about the pro...
The journey of developing hematopoietic stem cells. Development. 2006, 133(19): 3733-44. Goodell M A, Brose K, Paradis G et al. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 1996, 183(4): 1797-806. Christensen J L, ...
Embryonic Development Stem Cells & Regenerative Medicine General Gene Expression(119) Stem, Progenitor & Primary Cells(1) Images(1) Cellular Markers(0) Protocol-derived Cells(0) Literature HT comparisons & samples(1) Diseases & Cell Therapies(0) Incoming Signals(0) Outgoing Signals(1) ...
摘要: ► Current knowledge about hematopoietic stem cell ontogeny in vertebrate embryos ► Intrinsic/transcription factors – SCL, Runx, and Gata2 – that direct HSC generation ► Developmental morphogens/factors that are extrinsic cues for HSC generation...
1、Hematopoietic Stem Cell and HSCTHematopoietic Stem Cell (HSC) 主要存在于造血器官的、具有自我更新(self-renewal)和多向分化潜能(multi-differentiation),能够分化发育为各种外周血细胞的幼稚细胞。HSC的起源的起源(yolk sac)羊膜囊羊膜囊绒毛绒毛体蒂体蒂上胚层上胚层卵黄囊卵黄囊胚外中胚胚外中胚层层胚外体腔...
stem cell but has not been described in HSC expansion, is the JNK signaling pathway13,14,15, which also participates in the development of leukemogenesis16,17. Thus, we tested a panel of JNK-related small molecules for their ability to stimulate the expansion of human CD34+CD45RA−CB ...
Thus, common lymphoid progenitors exist in early hematopoiesis, and expression of the IL-7R is a critical step in the initiation of lymphoid development from HSC. 展开 关键词: hematopoietic stem cells interleukin-7 common lymphoid progenitor Bcl-2 ...
We asked whether the detailed and time-resolved HSC fate mapping data (Fig.1e) contain information on lineage pathways. In the case of lymphoid development, label from ES HSCs clearly arrived in progenitors before it entered mature cells (e.g., common-lymphoid progenitors (CLPs) and B cells...