Humoral immunity requires interaction between specialized populations of B cells and CD4T cells, called follicular helper T cells (Tcells), in the germinal center (GC) to produce memory B cells and long-lived plasma cells. Molecular crosstalk between GC B cells and Tcells influences the sur...
Do helper T-cells cause B-cells to divide? How do helper T cells activate B cells? Do memory cells interact with helper T-cells? Are effector T-cells the same as helper T-cells? How is CTLA 4 activated in helper T-cells? What is the function of helper T cells?
IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism. Humoral immunity requires cross-talk between T follicular helper (Tfh) cells and B cells. Nevertheless, a detailed understanding of this intercellular...
GC formation requires specialized CD4 T cells, T-follicular helper (Tfh) cells, which localize to follicles and provide B cells with survival and differentiation signals that are essential for B-cell maturation into memory and long-lived plasma cells. Pathogenic autoantibodies in human and murine ...
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T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The qua...
Summary: Development of germinal center (GC) B cells and follicular helper T (Tfh) cells requires the transcription factor B-cell lymphoma 6 (Bcl6). Expression of Bcl6 in B cells and helper T cells is regulated by complex signals including those generated through their antigen-specific interact...
T helper (Th) cells play important roles in adaptive immune responses, as they participate in the elimination of infected cells and pathogens together with macrophages, B cells, and T cells. When activated, Th cells can transdifferentiate into Th1, Th2, or Th17 cells, each with specific activ...
T cells recognizing tissue-restricted autoantigen is far from complete.14,15As a result, follicular activation of BDA-recognizing B cells may lead to a bona fide T-dependent autoreactive B cell response in normal animals. In the current study, we explored this hypothesis and showed that BDA-...
Cross-talk between gammadelta T lymphocytes and immune cells in humoral response. The role of γδ T cells in immunoregulation is largely unknown. In the current study we noted that γδ T cells play a positive role in the humoral respon... M Szczepanik,B Nowak,PW Askenase,... - 《Imm...