The present invention provides a heat-stable enzyme having a DNA helicase activity, and preferably a structure-specific endonuclease activity. This enzyme can be obtained by cloning a gene encoding the enzyme from chromosomal DNA of a hyperthermophile, preferably a sulfur-metabolizing thermophilic arch...
Helicases can also be classified according to the directionality of their translocation along DNA/RNA. These enzymes often require a region of single-stranded DNA (ssDNA) to bind to, before initiating unwinding of an adjacent region of the duplex. The helicase enzyme then translocates unidirectionall...
It has been proposed that the MCM helicase may act as a double-strand DNA translocase that pumps duplex DNA into the double hexamer in a manner analogous to that of the SV40 large T antigen or the bacterial RuvAB Holliday junction branch-migration enzyme (Figure 1). Under this scenario, ...
性质: 又称松旋酶(unwinding enzyme;unwindase;unwinding protein)。在环形DNA分子复制的时候保护或恢复双链DNA螺旋结构的酶。这些酶会使环状DNA产生一个缺口,并让断裂处DNA链自由转动。在超螺旋除去后再次封闭起来。 说明:补充资料仅用于学习参考,请勿用于其它任何用途。
Authors: Dimitrios Vlachakis, Andrea Brancale, Colin Berry & Sophia Kossida ### A new assay for the measurement of helicase enzyme activity was developed for the evaluation of the potency of potential inhibitors. This assay involves the use of a DNA or RNA duplex substrate and recombinant ...
美['helɪkeɪz] 英['helɪkeɪz] n.解螺旋酶;蜗牛酶 网络解旋酶;解螺旋酵素;解链酶 英汉 英英 网络释义 n. 1. 解螺旋酶 2. 蜗牛酶 例句
Samuelsson, J. et al. (2016) `Helicase Lymphoid-Specific Enzyme Contributes to the Maintenance of Methylation of SST1 Pericentromeric Repeats That Are Frequently Demethylated in Colon Cancer and Associate with Genomic Damage', Epigenomes, 1(1), p. 2....
- After helicase unwinds the DNA, the next enzyme to act is topoisomerase. This enzyme alleviates the torsional strain that builds up ahead of the replication fork due to the unwinding of the DNA. It prevents the DNA strands from becoming tangled or supercoiled. ...
Achilles was immortal, except for the one heel that turned out to be his downfall — he was shot there by Paris'arrow. Two papers in the April issue of Nature Medicine identify the herpes simplex virus (HSV) helicase–primase enzyme as a potential viral Achilles' heel....
Processive translocation and DNA unwinding by individual RecBCD enzyme molecules RecBCD enzyme is a processive DNA helicase and nuclease that participates in the repair of chromosomal DNA through homologous recombination. We have visual... PR Bianco,LR Brewer,M Corzett,... - 《Nature》 被引量: ...