In humans, the function and structure of blood vessels can be affected by a number of different diseases and conditions. Some examples includeinflammation;atherosclerosis, which involves thedepositionof fat in the arterial endothelium; andhypertension, in which narrowing of the arterioles causes an abno...
To learn more about the processes underlying the successful regeneration of the heart in zebrafish, the researchers used a technique called single cell RNA sequencing on the heart muscle cells in the border zone. With this technique, they were able to investigate the activity of all possible genes...
The heart consists of a range of tissues. The most important one is cardiac muscle. The cells have the ability to contract and relax through the complete life of the person, without ever becoming fatigued. Each cardiac muscle cell is myogenic. This means it has its own inherent rhythm. Belo...
Muscle contraction depends on strictly controlled Ca2+transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic reticulum Ca2+ATPase, SERCA. Activity of SERCA is regulated by binding of micropeptides and impaired expression or function of these peptides results...
Yes, for years, scientists have known that adult stem cells can be found in the heart. This has prompted numerous centers in many countries to pursuestem cell therapeuticsin patients with heart attacks, heart failure, and even severe angina to repair muscle and improve blood supply. ...
A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells, fibroblasts, immune cells, and among others, which work together to maintain optimal cardiac function. These cells engage in complex communication networks, known as cell-cell interactions (CCIs), which are essent...
Heart muscle degeneration results in loss of live cardiomyocytes, contractile filaments, contractility, heart function and healthy circulation. The damaged heart responds by cell division of cardiomyocytes. However, such regenerative capacity is hardly significant. Cardiomyocytes in culturowill undergo no mor...
Patients givenstem cell therapyalso had, on average, a longer amount of time until their first adverse event. Other measures of heart function and quality of life, including a walking endurance test and a measurement of the amount of blood pumped out of the left ventricle with each contraction...
cell death caused due to detachment [70]. Hence, collagen glycation may hinder the interaction of ECM with the cell and reduces the viability and function of angiogenic cells, causing decreased vascularization in the myocardial infarction area [69]. Experimental and clinical studies in diabetic ...
The way the heart muscle functions appears to be much more complex than previously assumed. This is the conclusion of a world-wide study in which data from 73,518 individuals from all across the world were used to search for new heart genes.