The pumping of the heart, or theheartbeat, is caused by alternating contractions and relaxations of the myocardium. These contractions are stimulated by electrical impulses from a natural pacemaker, thesinoatrial, or S-A, node located in themuscleof the rightatrium. An impulse from the S-A nod...
The heart consists of a range of tissues. The most important one is cardiac muscle. The cells have the ability to contract and relax through the complete life of the person, without ever becoming fatigued. Each cardiac muscle cell is myogenic. This means it has its own inherent rhythm. Belo...
Yes, for years, scientists have known that adult stem cells can be found in the heart. This has prompted numerous centers in many countries to pursuestem cell therapeuticsin patients with heart attacks, heart failure, and even severe angina to repair muscle and improve blood supply. The work ...
Muscle contraction depends on strictly controlled Ca2+transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic reticulum Ca2+ATPase, SERCA. Activity of SERCA is regulated by binding of micropeptides and impaired expression or function of these peptides results...
In endothelial cells expression and function of BK Ca channels play an important role in the regulation of the vascular smooth muscle activity. Endothelial ... B Eichhorn,D Dobrev - Naunyn-Schmiedeberg's archives of pharmacology 被引量: 188发表: 2007年 Dihydropyridine-sensitive calcium channels from...
Patients givenstem cell therapyalso had, on average, a longer amount of time until their first adverse event. Other measures of heart function and quality of life, including a walking endurance test and a measurement of the amount of blood pumped out of the left ventricle with each contraction...
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function Article Mechanical stimulation of induced pluripotent stem cell derived cardiac fibroblasts Article Cardiomyocyte and stromal cell cross-talk influences the pathogenesis...
Heart muscle degeneration results in loss of live cardiomyocytes, contractile filaments, contractility, heart function and healthy circulation. The damaged heart responds by cell division of cardiomyocytes. However, such regenerative capacity is hardly significant. Cardiomyocytes in culturowill undergo no mor...
cell death caused due to detachment [70]. Hence, collagen glycation may hinder the interaction of ECM with the cell and reduces the viability and function of angiogenic cells, causing decreased vascularization in the myocardial infarction area [69]. Experimental and clinical studies in diabetic ...
cell division. These molecules act through another signaling molecule called b1 integrin, found on the surface of cardiomyocytes. The team confirmed their observations in mutant mice that lacked b1 integrin. The mutant mice had fewer myocardial cells and disruptions of the muscle integrity that ...