Genetics and congenital heart disease - Emanuel - 1970 () Citation Context ...ividuals with DS is dramatically increased compared with the frequency observed in the general population. For example, only 5–7 in 1,000 non-trisomic newborns are estimated to have some form of CHD [=-=Emanuel,...
Coronary heart disease (CHD) is the single leading cause of death in America, accounting for about one of every five deaths [1]. Family history of premature parental CHD is associated with a twofold increased risk of cardiovascular disease, making it vital that providers know their patients' ...
CRISPR–Cas9 is a versatile tool for recognizing a specific genomic sequence and inducing a double-strand break (DSB) in the DNA.doi:10.1038/nrcardio.2017.128LimGregory BNature Reviews CardiologyLim GB (2017) Gene therapy: Human genome editing in heart disease. Nat Rev Genet 18:580....
Heart failure is a major problem in the patient with congenital heart disease. Normally interpreted as a sequela of surgical interventions or abnormal preoperative loading conditions, there is increasing evidence that congenital heart malformations and abnormal ventricular function can have the same underly...
Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or en...
Genetics of Congenital Heart Disease: Is the Glass Now Half-Full? Congenital heart defects are present in 1% of all live births and are a significant burden on the parents and family, healthcare system, and overall commun... L Leatherbury,CI Berul - 《Circulation Cardiovascular Genetics》 被...
It begins with a historical perspective of congenital heart diseases, surgery and interventions, and perspectives of the start and continuation of the Pediatric Cardiac Care Consortium. The text is then divided into diagnoses and includes a bit of natural history plus pathophysiology, as well as ...
The role of genetics in heart disease diagnosis and management is expanding daily. Clear genetic components have been found for diseases such as hypertrophic cardiomyopathy, heart failure, and coronary artery disease. Rhythm disturbances with genetic components are atrial fibrillation and long QT syndrome...
Ordovas, a biochemist at Tufts University in Boston, Massachusetts, the study sheds light on how obesity modifies the risk of heart disease among carriers of a particular gene variant. The study also sought to appraise the relationship of carriers of variants of the APOA5 gene to atherosclerosis...
Cardiovascular genetic medicine: the genetics of coronary heart disease. J Cardiovasc Trans Res. 2008;1:166-170.David, SeoPascal J., Goldschmidt-Clermont. (2008) Cardiovascular Genetic Medicine: The Genetics of Coronary Heart Disease. Journal of Cardiovascular Translational Research 1 , 166-170 /...