Continuous glucose monitoring data obtained during the week before the study day were used to assess the extent of hypoglycaemia exposure.#While glucose responses during the clamp were similar between people with type 1 diabetes and healthy participants, plasma concentrations of NEFAs and glycerol only...
Outside of case–control settings, ethnicity specific changes in the human metabolome are understudied especially in community dwelling, ageing men. C
Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans Article Open access 25 August 2023 The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. el...
In this study, optimized processing of the Allen Human Brain Atlas revealed two new components of cortical gene expression architecture, C2 and C3, which are distinctively enriched for neuronal, metabolic and immune processes, specific cell types and cytoarchitectonics, and genetic variants associated...
Sleeping metabolic rate was calculated as the lowest average 3-h energy expenditure during the sleeping period. Glucose oxidation and fat oxidation rates were calculated according to Péronnet and Massicotte (41, 42). Steele’s single-pool non–steady state equations were used to calculate the ...
The SCFAs that are not used by the colonocytes travel to the liver and will be used in gluconeogenesis (a metabolic pathway that produces glucose from non-carbohydrate substances) and lipid (fat) synthesis. So SCFAs provide an energy source for the human host. SCFAs can even act as ...
In addition to assisting in the digestion and assimilation of fats and fatty compounds, reabsorbed bile acids and their byproducts help regulate lipid and glucose metabolism and energy production (Taoka 2016; Ryan 2017). How bile acids modulate cardio-metabolic conditions such as obesity, diabetes,...
The inhibition of this process triggered fat accumulation in other fat depots and abdominal organs, leading to systemic glucose intolerance, which is reminiscent of the pattern in metabolically unhealthy obese patients. Can Angpt2 treatment be a therapeutic strategy to normalize fat distribution and tre...
metabolic pathways. The “core” metaproteome included 182 microbial functions and 83 pathways that were identified in all individuals analyzed. Several enzymes involved in glucose and pyruvate metabolism, along with glutamate dehydrogenase, acetate kinase, elongation factors G and Tu and DnaK, were ...
(h2 = 0.40,p < 0.001) healthy metabolic profile, comprised of age and gender adjusted z-scores for favourable fasting levels of glucose, insulin, triglycerides, high-density lipoprotein cholesterol, body mass index, waist circumference, interleukin-6 and high-sensitivity C-reactive protein...