The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the C
Blood-brain barrier permeability in "healthy" infected and stressed neonates. J Pediatr. 1992; 121: 291-294.Anagnostakis D, Messaritakis J, Damianos D, Mandyla H. Blood- brain barrier permeability in "healthy" infected and stressed neo- nates. J Pediatr 1992;121:291-294...
Many studies have shown that it can act as a potent antioxidant that, through its amphiphilic properties, allows it to cross physiological barriers, such as the blood–brain barrier, thereby reducing the level of oxidative damage in the aqueous and lipid cell environments. It also characteristically...
The Mammalian Brain in the Electromagnetic Fields Designed by Man with Special Reference to Blood-Brain Barrier Function, Neuronal Damage and Possible Phys... Life on earth was formed during billions of years, exposed to, and shaped by the original physical forces such as gravitation, cosmic irrad...
Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan. Thus, all genes in the pathways are potential antiaging targets. Currently, many antiaging compounds target the calorie-restriction mimetic, autophagy induction, and putative enhancement of cell ...
First, it is considered a “super antioxidant”, having the ability to significantly reduce free radicals and oxidative stress, without having the capability of becoming a pro-oxidant, even at very high levels. Second, astaxanthin can cross the blood-brain barrier, making it particularly beneficial...
The blood-brain barrier (BBB) maintains brain homeostasis by controlling traffic of molecules from the circulation into the brain. This function is predominantly dependent on proteins expressed at the BBB, especially transporters and tight junction proteins. Alterations to the level and function of BBB...
Many countries are witnessing a marked increase in longevity and with this increased lifespan and the desire for healthy ageing, many, however, suffer from
Brain endothelial cells form the blood–brain barrier (BBB) and play a key role in providing the special homeostatic internal milieu required for optimal functioning of central nervous system (CNS) neurons. To accomplish this, endothelial cells cooperate with mural cells such as pericytes and smooth...
Brain function is governed by precise regulation of gene expression across its anatomically distinct structures; however, the expression patterns of genes across hundreds of brain structures are not clearly understood. Here, we describe a gene expression model, which is representative of the healthy hum...