The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many s
The authors review how the blood鈥揵rain barrier, a regulatory interface that controls interactions between the blood and central nervous system, changes during healthy aging, and discuss how some of these changes may predispose to age-associated diseases....
Single-cell transcriptomic profiling of the aging mouse brain Article 24 September 2019 A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains Article Open access 30 November 2023 Deconvolution reveals cell-type-sp...
When you’re on the go, choosing nutrient-dense foods can help you get the most nutritional value from your meals and snacks, even if you’re limited on time. Opt for foods rich in vitamins, minerals, fiber, and protein, which provide sustained energy and support various bodily functions. ...
In healthy brains, the cells that form the walls of capillaries fit tightly together to form a barrier that keeps stray cells, pathogens, metals and other unhealthy substances from reachingbrain tissue. Scientists call this theblood-brain barrier. In some aging brains, the seams between cells loo...
The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Revi
Vitamin C acts as a powerful detoxifier thatreadily crosses the blood-brain barrierto remove metals likealuminum, which has long been suspected of contributing to Alzheimer’s, from the brain. A landmarkUniversity of Oxford studyfound that vitamins B6, B12, and folic acid, which are abundant ...
One of the most important factors in active aging is regular physical activity. Caregivers can introduce seniors to simple exercises such as walking, stretching, or light strength training. Activities like gardening, swimming, or yoga not only improve mobility and strength but also enhance mood and...
Cerebral edema, also called ARIA-E, is the main risk. It involves the breakdown of the tight endothelial junctions of the blood-brain barrier and results in the accumulation of fluid in the brain. In general, common side effects of ARIA-E include easy bruising/bleeding, numbness/tingling of...
Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485–496 (1995). Article CAS PubMed Google Scholar Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms....