The authors review how the blood鈥揵rain barrier, a regulatory interface that controls interactions between the blood and central nervous system, changes during healthy aging, and discuss how some of these changes may predispose to age-associated diseases....
The blood-brain barrier in brain homeostasis and neurological diseases exchanges between the blood and the brain compartments by limiting passive diffusion of blood-borne solutes while actively transporting nutrients to the brain... N Weiss,F Miller,S Cazaubon,... - 《Biochim Biophys Acta》 ...
The Mammalian Brain in the Electromagnetic Fields Designed by Man with Special Reference to Blood-Brain Barrier Function, Neuronal Damage and Possible Phys... Life on earth was formed during billions of years, exposed to, and shaped by the original physical forces such as gravitation, cosmic irrad...
Its potential to prolong longevity has been repeatedly described in fruit flies and mice [128-130]. Many studies have shown that it can act as a potent antioxidant that, through its amphiphilic properties, allows it to cross physiological barriers, such as the blood–brain barrier, thereby ...
First, it is considered a “super antioxidant”, having the ability to significantly reduce free radicals and oxidative stress, without having the capability of becoming a pro-oxidant, even at very high levels. Second, astaxanthin can cross the blood-brain barrier, making it particularly beneficial...
Water exchange across blood‐brain barrier is associated with CSF amyloid‐42 level in healthy older adults: Neuroimaging / Optimal neuroimaging measures for early detection doi:10.1002/alz.036794Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationGold, Brian TShao, Xingf...
Bridging the Blood-Brain Barrier: New Methods Improve the Odds of Getting Drugs to the Brain Cells That Need Them Trojan horses can also deliver large molecules that would never stand a chance of crossing the barrier otherwise, including enzymes, monoclonal antibody drugs, RNA interference, and ge...
Brain function is governed by precise regulation of gene expression across its anatomically distinct structures; however, the expression patterns of genes across hundreds of brain structures are not clearly understood. Here, we describe a gene expression model, which is representative of the healthy hum...
et al. The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154, 430–441 (2013). Article CAS PubMed PubMed Central Google Scholar Kondratov, R. V. A role of the circadian system and circadian proteins in aging. Ageing Res. Rev. ...
Moreover, the presence of a common transporter that crosses the blood–brain barrier results in competition between KYN and TRP [14]. Therefore, dysregulation of the balance between metabolites of the KYN and serotonin pathways is associated with an increased risk of stress, anxiety, and ...