There has been "no drop in operational standards", the head of the RAF has said, after its head of recruitment described a policy on diversity as "unlawful". Sky News reported last month that a group captainrefused to follow an order to prioritise women and ethnic minority candidates. She ...
In innate immune sensing, further investigations should also focus on how TMEM16A overexpression modulates intratumoral lymphocyte populations and surrounding T lymphocyte recruitment and their functions. Dr Laura Conforti mentioned that Ca2+ is in fact a key regulator of the activity of important ...
Immunotherapy has evolved into a powerful tool in the fight against a number of types of cancer, including head and neck squamous cell carcinomas (HNSCC). Although checkpoint inhibition (CPI) has definitely enriched the treatment options for advanced stage HNSCC during the past decade, the ...
A phase I study of a CDK inhibitor in combination with radiation has recently completed recruitment (NCT00899054, Table 1). Table 1 Targeted therapies in HNSCC Full size table Epidermal Growth Factor Receptor (EGFR) Pathway EGFR (ErbB1) is a member of the ErbB/HER2 family of transmembrane ...
Many cancer therapies aim to trigger apoptosis in cancer cells. Nevertheless, the presence of oncogenic alterations in these cells and distorted composition of tumour microenvironment largely limit the clinical efficacy of this type of therapy. Luckily,
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC. Despi
Related:JM Search Assists LiiV in the Recruitment of New CFO Contributed by Scott A. Scanlon, Editor-in-Chief; Dale M. Zupsansky, Managing Editor; and Stephen Sawicki, Managing Editor – Hunt Scanlon Media
Mutations in Kirsten rat sarcoma virus (KRAS), neuroblastoma-RAS (NRAS), and B-RAF have also been demonstrated to be involved in the initiation and pro- gression of CRC [42]. TMEM16A is also overexpressed in hepatocellular carcinoma, and that the inhibition of TMEM16A suppressed MAPK and ...
With the understanding of the complex interaction between the tumour microenvironment and immunotherapy, there is increasing interest in the role of immune regulators in the treatment of head and neck squamous cell carcinoma (HNSCC). Activation of T cell
head and neck cancer Z Zhou1,2, M Wang1, J Li2, M Xiao3, YE Chin3, J Cheng1, ETH Yeh4, J Yang1 and J Yi1 Hyperphosphorylation of signal transducer and activator of transcription 3 (STAT3) has been found in various types of human cancers, including head and neck cancer (HNC)....