Cryo-EM structure of a RAS/RAF recruitment complex Article Open access 29 July 2023 Introduction The MAPK pathway (RAS/RAF/MEK/ERK) is a cascade of protein-protein interactions that transmits signals from cell-surface receptors to the nucleus, where cellular programs for proliferation and surviva...
TRAF recruitment activates various MAPKKKs involved in the activation of p38 isoforms. The p38 isoforms are also activated by GPCRs [30], as well as by the Rho family GTPases Rac and Cdc42 [31]. It is believed that MKK3 and MKK6 are the main protein kinases responsible for the ...