ABCA1 and ApoE are upregulated by liver-X receptors. Activation of liver-X receptors has neurorestorative benefit for stroke. The current study investigates whether ABCA1/ApoE/HDL pathway mediates GW3965, a synthetic dual liver-X receptor agonist, induced neurorestoration after stroke.Cui, Xu...
HDL also potently protects endothelial cells against growth factor deprivation-induced apoptosis via suppression of the mitochondrial apoptotic pathway (64). Both apoA-I (62) and sphingosine-1-phosphate (65, 66), a lipid component of HDL, have been proposed to contribute significantly to HDL-...
图4. HDL载脂蛋白绝对定量结果 6. 建立了HDL各馏分SAAM Ⅱ体内代谢动力模型(图5示例图展示其中APOA2的Source和Removal pathway)。 图5. APOA2代谢动力模型示例图 小编心得 本篇文献是利用PRM蛋白质靶向技术,对低丰度表达的HDL各个馏分进行绝对定量分析,发表在J Lipid Res上的方法性研究论文。文中探索了应用PRM技...
Due to the large biological/genetic variation and lifestyle of people, it is difficult to gain clear insight into the relation between the flux of cholesterol through the HDL pathway and the development of atherosclerosis—the primary underlying cause of cardiovascular disease—in the general human ...
HDL's ability to participate in the reverse cholesterol transport (RCT) pathway is, therefore, likely an important part of its anti-atherogenic role. We are now beginning to realize the full breadth of HDL's function and cargo; thus, there is a significant need to begin to rethink and ...
R. HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. J. Clin. Invest. 116, 1435–1442 (2006). Article CAS PubMed PubMed Central Google Scholar Ishigami, M. et al. Large and cholesteryl ester-...
First, despite a renewed interest in HDL research we still do not completely understand how HDL protects against atherosclerosis. The prevailing hypothesis is that it potentiates the reverse cholesterol transport pathway but the other beneficial effects of HDL may also contribute to its atheroprotective ...
In previous chapters, we know that high-density lipoproteins (HDLs) could act at multiple cell lines and then trigger intracellular molecular pathway to prevent several metabolic diseases. Besides the classic genes regulating cholesterol efflux and reverse cholesterol transport (RCT), microRNAs (miRNAs)...
Plant fiber and polyphenols have been reported to raise HDL. For instance, a polyphenol-rich carob fiber was found to raise HDL by 7% while lowering LDL [24], and psyllium has been reported to raise HDL [25]. It is unclear to me whether this is a beneficial pathway or not. On the ...
[9]. Virani SS, Morris PB, Agarwala A, et al. 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia: A Report of the American College of Cardiology...