HDL stimulation of endothelial nitric oxide synthase: a novel mechanism of HDL action. Trends Cardiovasc. Med. 13, 226-231.Mineo C, Shaul PW. HDL stimulation of endothelial nitric oxide synthase: A novel mechanism of HDL action. Trends Cardiovasc Med 2003;13:226-31....
HDL-replacement therapy: mechanism of action, types of agents and potential clinical indications. Expert Rev. Cardiovasc. Ther. 6, 1203–1215 (2008). Article CAS PubMed PubMed Central Google Scholar Verschuren, L., de Vries-van der Weij, J., Zadelaar, S., Kleemann, R. & Kooistra, ...
Bioactive compounds and mechanism of action The mRNA levels of activating protein (AP2) are downregulated byA. cepaandfatty acid binding protein 4(FABP4) and carnitine palmitoyl transferase-1 α (CPT-1α) are upregulated by this. An essential oil is a principal constituent containing varioussulf...
In this article, we review the mechanism of action for the postulated antiatherogenic effect of HDL-C and how current and future therapies can exploit this beneficial activity. The clinical evidence supporting various interventions to raise HDL-C, from lifestyle modifications to established drugs (e...
The particle size of sHDL was further confirmed with transmission electron microscopy (TEM) imaging (Fig. 1d). Gel permeation chromatography (GPC) results suggested a uniform size distribution of sHDL particles (Fig. 1e). Fig. 1 Mechanism of action, preparation, and characterization of sHDLs....
the mechanism of discoidal HDL formation, proposing that lipid-free ApoA-I interacts with macrophage membranes via ATP-binding cassette transporter A1 (ABCA1), binding phospholipids and free cholesterol to form discoidal HDL [27,28,29,30]. Subsequent studies gradually confirmed this formation process...
Wire-names serve as the mechanism for schematic "connections by name". Any two wires with the same name shall be considered connected. There is one specialwire-namevalue: the empty string, which implies that (a) the wire's is not explicitly set, and (b) importers shall assign it a net...
The in vitro mechanism of the action of the new peptides were explored. Adult apolipoprotein E-/- mice were used to evaluate the anti-atherosclerotic activity of the best candidate, and the mechanistic basis of its anti-atherosclerotic effects were explored. Key results: Seventeen new AMPs (P1...
Mechanism of action of fibrates on lipid and lipoprotein metabolism Circulation., 98 (1998), pp. 2088-2093 View in ScopusGoogle Scholar 177. Birjmohun R.S., Hutten B.A., Kastelein J.J.P., Stroes E.S.G. Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: A...
Thus, it was not clear whether the clinical failure of torcetrapib was due to off-target toxicity or to a detrimental mechanism of action (Rader, 2007a, Tall, 2007, Tall et al., 2007). There has been considerable speculation that the strategy of CETP inhibition might lead to formation of...