(2013) Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem. Biol. 20, 713- 725.Stacey M. Frumm, Zi Peng Fan, Kenneth N. Ross, Jeremy R. Duvall, Supriya Gupta, Lynn VerPlank, Byung-Chul Suh, Edward Holson, Florence F. Wagner, William B. Smith, ...
While cytotoxic chemotherapy remains the hallmark of cancer treatment, intensive regimens fall short in many malignancies, including high-risk neuroblastoma. One alternative strategy is to therapeutically promote tumor differentiation. We created a gene expression signature to measure neuroblast maturation, ada...
Purpose : Preliminary data demonstrate significant down-regulation of HDAC1/2 expression in the RPE of eyes with atrophic age-related macular degeneration (AMD). RPE cytotoxicity and patterned inflammatory gene expression were observed after Class I HDAC inhibition in vitro and in vivo. In this study...
Low-Dose Deguelin, Selective Targeting of Mt NPM1, Induces Differentiation in NPMc+ AML Cells By Regulation the Axis of SIRT1/CEBPβ/G-CSFR, Instead of HDAC1/3 Author links open overlay panelYouping Wang * 1, Zichu Zhao * 1, Jingyu Hu * 1, Fei Zhao * 1, Jing He * 2, Jun Fang...
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1 and/or HDAC2. Such diseases include cancer, ...
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1 and/or HDAC2. Such diseases include cancer, ...
N. et al. Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem. Biol. 2013, 20, 713‐725.Frumm SM, Fan ZP, Ross KN, Duvall JR, Gupta S, VerPlank L, Suh BC, Holson E, Wagner FF, Smith WB, Paranal RM, Bassil CF, Qi J, Roti G, Kung AL, Bradner JE, ...
SELECTIVE HDAC1,2 INHIBITORSProvided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.JOHN H. VAN DUZERRALPH MAZITSCHEK...
SELECTIVE HDAC1,2 INHIBITORSProvided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.JOHN H. VAN DUZERRALPH MAZITSCHEK...
X. Li, W. Xu, HDAC1/3 dual selective inhibitors - new therapeutic agents for the potential treatment of cancer, Drug. Discov. Ther. 8 (2014) 225-228.Li X, Xu W. HDAC1/3 dual selective inhibitors - new therapeutic agents for the potential treatment of cancer. Drug Discov Ther 2014; ...