In the 2 HCV-RNA negative specimens the scanty immunopathological staining could indicate a residual activity due to the previous inflammatory event triggered by cryoglobulins. The deposition of circulating HCV-containing immune complexes (CIC) in the skin could be the initial pathogenic event for ...
No significant differences were found in the liver enzyme values between the HCV antibody-negative, HCV RNA positive and the HCV antibody positive, HCV RNA positive individuals. Histological samples from two HCV RNA positive, HCV antibody-negative patients disclosed the presence of a mild liver ...
Among the 1,049 enrolled IDUs, 136 patients had HBV single infection (HBsAg+), 340 patients had HCV single infection (HCV RNA+), and 42 patients had dual infection with HBV and HCV (HBsAg+ and HCV RNA+). The median ages of patients with HBV single infection, HCV single infection, and...
(HCV RNA-positive patients, within one month from the ALT peak; T1/early time-point) and at later stages of resolution (HCV RNA-negative patients, at least 12 months after the ALT peak; T2/late time-point) or chronic evolution of infection (HCV RNA-positive patients, followed for at ...
However, after any episode of dialysis in a different unit (especially one in a different country) it would probably be prudent for individuals to have HCV RNA testing once every 2-3 months for the first 6 months on return to their base dialysis unit. How and how often should HCV ...
No significant differences were found in the liver enzyme values between the HCV antibody-negative, HCV RNA positive and the HCV antibody positive, HCV RNA positive individuals. Histological samples from two HCV RNA positive, HCV antibody-negative patients disclosed the presence of a mild liver ...
(ELISA) and a quantitative HCV RNA assay based on reverse transcription-PCR (RT-PCR) (Amplicor HCV Monitor test) was performed using a large (n = 305) cohort of ELISA HCV 3.0 HCV-negative and -positive patients on maintenance dialysis. The concentrations of HCV core Ag and HCV RNA levels...
As an infected cell presenting foreign antigen, the hepatocyte will interact with a large number of lymphocytes, both by direct cell to cell contact and by indirect means through the secretion of cytokines and chemokines. These interactions may lead on the one hand to the death of infected ...
The positive-sense RNA virus continues to cause severe morbidity and mortality among people who are infected through intravenous drug use, contaminated blood products and unsafe medical procedures. To date, there are six confirmed genotypes denoted as genotype 1 through 6 and a provisionally assigned ...
HCV replicates through the production of a complementary negative-strand RNA template.HCV is a genetically diverse virus. Within a single infected patient, many variant viruses can be identified, leading to the description ‘viral swarm’, or viral quasispecies. Within the global human population, ...