HCV is a positive-stranded RNA virus belonging to the Flaviviridae family and has closest relationship to the pestiviruses that include hog cholera virus and bovine viral diarrhea virus.The HCV genome is a single-stranded, positive-sense RNA of about 9,600 bp coding for a polyprotein of 3009...
Mutations yielding a negative change in energy imply an increase in fitness, whereas those yielding a positive energy change would imply a fitness decrease. Quite strikingly, our model predicted four mutations at residue 444 (Q444H, Q444V, Q444Y, and Q444R) to be associated with the most ...
Hepatitis C virus (HCV) infection is a blood-borne RNA virus of the genusHepacivirusand familyFlaviviridaewith the potential to cause liver fibrosis, hepatocellular carcinoma, and liver-related deaths [1,2]. The global prevalence of viremic (HCV-RNA positive) HCV infection worldwide was estimate...
PLWH who had received HAART for at least 6 months were included in this study from 2017 to 2022 if HCV-Ab positive and with a positive test for HCV-RNA. Inclusion criteria were: (1) established diagnosis of HCV chronic hepatitis as assessed by detectable HCV-RNA; (2) co-presence of HIV...