(3) 探究药物对结直肠癌治疗的敏感性和耐药性。例如:Doxorubicin抑制HCT116细胞中miR-140的表达而上调PD-L1,从而使肿瘤细胞对药物产生耐药性[4](4) 开发新的癌相关信号通路,为临床治疗结直肠癌提供指导:例如,研究Notch和Wnt信号通路在结直肠癌细胞HCT116耐药中的意义等[5](5) 开发LncRNA和miRNA在结直...
(3) 探究药物对结直肠癌治疗的敏感性和耐药性。例如:Doxorubicin抑制HCT116细胞中miR-140的表达而上调PD-L1,从而使肿瘤细胞对药物产生耐药性[4] (4) 开发新的癌相关信号通路,为临床治疗结直肠癌提供指导:例如,研究Notch和Wnt信号通路在结直肠癌细胞HCT116耐药中的意义等[5] (5) 开发LncRNA和miRNA在结直肠癌治...
(3) 探究药物对结直肠癌治疗的敏感性和耐药性。例如:Doxorubicin抑制HCT116细胞中miR-140的表达而上调PD-L1,从而使肿瘤细胞对药物产生耐药性[4] (4) 开发新的癌相关信号通路,为临床治疗结直肠癌提供指导:例如,研究Notch和Wnt信号通路在结直肠癌细胞HCT116耐药中的意义等[5] ...
suggesting that 24 h supernatant contains CXCL16 and CCL28, whereas HCT-116 secretes all three chemokines after 48 h in vitro cultures. CXCL16, CCL27, and CCL28, as well as the supernatants collected from HCT-116, induced the mobilization of (Ca)2+in NK92 cells. Cross-desensitization...
PD-1 expression is increased in the T cells of patients with pancreatic cancer, lung cancer, and various leukemias and lymphomas [51]. Therefore, PD-1 expression in T cells and PD-L1 expression in tumor cells constitute a tumor escape mechanism. We observed reduced PD-1 expression on the ...
肿瘤干细胞dc疫苗与抗pd-l1抗体联用抗结肠癌的实验研究 热度: 细胞分化与基因表达调控 ,癌细胞 肿瘤干细胞.ppt 热度: CD44胃癌细胞的肿瘤干细胞特性鉴定及其与癌侵袭相关性研究 热度: 基金项目:上海市科委自然科学基金(09ZR1418700) 第一作者:**君,在读研究生。E-mail:feng_yj@hotmail.com ...
Colorectal cancer is one of the most common causes of cancer-related death in humans. Coptisine (COP) is a natural alkaloid from Coptidis Rhizoma with unclear antitumor mechanism. Human colon cancer cells (HCT-116) and xenograft mice were used to systema
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(3) 探究药物对结直肠癌治疗的敏感性和耐药性。例如:Doxorubicin抑制HCT116细胞中miR-140的表达而上调PD-L1,从而使肿瘤细胞对药物产生耐药性 (4) 开发新的癌相关信号通路,为临床治疗结直肠癌提供指导:例如,研究Notch和Wnt信号通路在结直肠癌细胞HCT116耐药中的意义等 ...
例如:Doxorubicin抑制HCT116细胞中miR-140的表达而上调PD-L1,从而使肿瘤细胞对药物产生耐药性 (4) 开发新的癌相关信号通路,为临床治疗结直肠癌提供指导:例如,研究Notch和Wnt信号通路在结直肠癌细胞HCT116耐药中的意义等 (5) 开发LncRNA和miRNA在结直肠癌治疗中的新途径。例如:在HCT116细胞中,YWHAE长链非编码RNA...