*使用本品系发表的文献需注明: HBV-Tg mice (Cat. NO. NM-TG-00003) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Fig1. Immuno-histochemical staining of HBsAg in the liver and kidney sections of #59 transgenic mice. Sections of liver (A) or kidney (B) tissues from ...
应用领域:乙型肝炎 *使用本品系发表的文献需注明: HBV-Tg mice (Cat. NO. NM-TG-00003) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Fig1. Immuno-histochemical staining of HBsAg in the liver and kidney sections of #59 transgenic mice. Sections of liver (A) or kidney...
这些结果提示，长期摄入乙醇可以使HBV-Tg小鼠的PBL和脾脏Treg比例增加。图5 乙醇摄入会增加HBV-Tg小鼠的PBL和脾脏的Treg细胞。（A）研究慢性乙醇摄入对小鼠PBL和脾脏Treg影响的策略。（B、D）流式细胞术显示每组小鼠的PBL或脾脏中CD3⁺ CD4⁺ CD25⁺ CD127⁻ Treg细胞。（C、E）每组小鼠的PBL或脾脏中的Tre...
取各组大鼠液氮冻存的肾脏组织,加入TRIzol试剂提取总RNA,逆转录合成cRNA,上PCR仪检测基因表达情况。Kim-1引物序列:上游引物5′-ACATATCGTGGAATCACAACGAC-3′、下游引物5′-ACAAGCAGAAGATGGGCATTG-3′,Oat1引物序列:上游引物5′-CTGA...
76. Zong, L., et al.,Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice.Nat Commun, 2019.10(1): p. 221. 77. Xu, Y., et al.,Tim-3 blockade promotes iNKT cell function to inhi...
Importantly, CCl4- induced the pro-fibrotic activation of liver cells, and liver stiffness was higher in HBVTg mice compared with control mice. Elevation of HBV markers and OPN levels corresponded to decreased ISG activation in HBVTg CCl4 mice vs HBVTg control mice. Con...
一座科大医学楼拔地而起，从人才引进到科研项目申报，中科大在1年的时间内收获颇丰，最近中科大生命科学与医学部、中科院天然免疫与慢性疾病重点实验室、合肥微尺度物质科学国家研究中心田志刚院士课题组发表了一篇《“Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice》论文，被国际...
we investigated HBV expression in HBV transgenic mice fed three levels of casein diet. HBV expression in transgenic animals was substantially inhibited when dietary casein was reduced from the traditional level of 22% to the level of 6%. Northern analysis revealed that suppression of HBV was derived...
Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice Hepatitis B virus (HBV) can induce chronic inflammation, cirrhosis, and eventually hepatocellular carcinoma (HCC). Despite evidence suggesting a link between adaptive immunity and HBV-related diseases in humans, the im...
应用领域:乙型肝炎 *使用本品系发表的文献需注明: HBV-Tg mice (Cat. NO. NM-TG-00003) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Fig1. Immuno-histochemical staining of HBsAg in the liver and kidney sections of #59 transgenic mice. Sections of liver (A) or kidney...