Cheng-ChiehInstituteYangInstituteKuo-WeiInstituteChangInstituteSpringerCancer & Metastasis ReviewsYang CC and Chang KW: Eicosanoids and HB‑EGF/EGFR in cancer. Cancer Metastasis Rev: 23 Jun, 2018 (Epub ahead of print).
Heparin binding epidermal growth factor-like growth factor (HB-EGF) is involved in development and homeostasis as well as in pathological processing of chronic diseases, especially cancer. Enhancement of HB-EGF expression is directly or indirectly regulated by transcriptional factors, including activator ...
前期的研究表明中药复方补肾安胎方能提高 tor,HB-EGF)是表皮生长因子家族中与胚泡着床胚泡着床障碍模型小鼠的着床率和胚泡着床位点 密切相关的因子,与问质细胞中EGFR相结合促进数,其机制可能与其促进种植窗期相关因子的表达 子宫内膜间质细胞的蜕膜化,可为胚泡着床作准 备[2]。本研究观察了补肾安胎方对胚泡着床...
To confirm the role of the endothelial-derived Hbegf–Egfr signalling pathway in beta cell proliferation, we assessed the beta cell proliferation rate response to HBEGF incubation. In MIN6 cells, HBEGF treatment significantly increased the expression of MKI67, cell viability and the proportion of...
Epiregulin is the newest member of the epidermal growth factor (EGF) family of ligands that was isolated from conditioned medium of the murine fibroblast-derived tumour cell line NIH3T3/T7. Here, using a panel of anti-EGFR receptor (EGFR) monoclonal antibodies (MAbs) directed against 4 distinct...
目的探讨宫颈高危型人乳头瘤病毒(HPV)感染患者血清肝素结合性表皮生长因子(HB-EGF),表皮生长因子受体(EGFR)表达水平以及患者阴道微生态失衡情况.方法选取2020年4月至2022年5月于河北省石家庄市人民医院就诊的169例宫颈炎患者作为研究对象,根据患者是否感染高危型HPV分为实验组(感染高危型HPV)88例,对照组(未感染高危...
检测实验组高危型HPV感染亚型,检测并比较两组患者阴道菌群分布状态和微生态平衡状态,检测两组血清HB-EGF和EGFR表达水平并进行比较,采用Spearman相关性分析高危型HPV感染与血清HB-EGF、EGFR水平及阴道微生态的相关性,采用Logisitic回归分析高危型HPV感染的影响因素。结果高危型HPV感染检测结果显示,HPV16检出率最高,其次是...
目的观察中药补肾安胎方对胚泡着床障碍模型小鼠胚泡着床情况及对类肝素结合样表皮生长因子(HB-EGF)及其受体(EGFR)表达的影响.方法将妊娠雌鼠随机分为正常组,模型组,中药组,每组30只,分别于妊娠第5,6天(Pd5,6)用伊文思蓝尾静脉注射后取妊娠子宫.观察妊娠第5天(Pd5)各组对伊文思蓝的着色反应;运用RT-PCR方法...
Combination of hb-egf binding protein and egfr inhibitorThe present application relates to the combined use of an antigen-binding protein that binds HB-EGF and an EGFR tyrosine kinase inhibitor in medical treatment.WALLASCH Esther ZWICK
目的探讨宫颈高危型人乳头瘤病毒(HPV)感染患者血清肝素结合性表皮生长因子(HB-EGF),表皮生长因子受体(EGFR)表达水平以及患者阴道微生态失衡情况.方法选取2020年4月至2022年5月于河北省石家庄市人民医院就诊的169例宫颈炎患者作为研究对象,根据患者是否感染高危型HPV分为实验组(感染高危型HPV)88例,对照组(未感染高危型...