Synonyms Diphtheria toxin receptor ; DTR ; DTS ; DTSF ; HBEGF ; HEGFL ; Heparin-binding epidermal growth factor-like growth factor Historical Background Since the discovery of epidermal growth factor (EGF) in 1962, a total of seven mammalian ligands that bind the EGF receptor ( EGFR /ErbB...
Dermo1-Cre;HBG-EGFf/f小鼠的骨量仅略有增加,而Dermo1-HB-EGF小鼠则发展为进行性软骨发育不良、软骨瘤、骨关节炎样关节缺陷以及骨量和密度的 缺损,这些都通过用EGFR抑制剂AG1478治疗得以缓解。软骨细胞特异性HB-EGF过度表达(Col2-HB-EGF)小鼠软骨缺损的严重程度较轻。Dermo1-HB-EGF小鼠增殖增加,但软骨细胞和成...
HB-EGF可与细胞表面的EGF受体(EGFR)和硫酸乙酰肝素蛋白多糖(HSPG)两种受体相结合而发挥其重要的生物学作用;其本身也是一种旁分泌、自分泌生长因子和粘附分子。已研究发现在人和动物子宫内膜有HB-EGF mRNA及其蛋白的表达,在子
结果显示与对照组相比,Il-4rαfl/flClec4f-Cre+/-小鼠肝脏中磷酸化(p)-表皮生长因子受体(p-EGFR)水平降低,表明肝巨噬细胞中的IL-4/IL-4Rα信号可以调节一种或多种EGFR配体。在IR损伤后第3天从Il-4rαfl/flClec4f-Cre+/-...
Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a ligand for the EGF receptor (EGFR) and a critical molecular component to a number of normal physiological processes including but not limited to tissue injury and wound healing, reproduction, angiogenesis and recently, ...
Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a ligand for the EGF receptor (EGFR), one of the most commonly amplified receptor tyrosine kinases (RTKs) in glioblastoma (GBM). While HBEGF has been found to be expressed in a subset of malignant gliomas, its ...
检测实验组高危型HPV感染亚型,检测并比较两组患者阴道菌群分布状态和微生态平衡状态,检测两组血清HB-EGF和EGFR表达水平并进行比较,采用Spearman相关性分析高危型HPV感染与血清HB-EGF、EGFR水平及阴道微生态的相关性,采用Logisitic回归分析高危型HPV感染的影响因素。结果高危型HPV感染检测结果显示,HPV16检出率最高,其次是...
前期的研究表明中药复方补肾安胎方能提高 tor,HB-EGF)是表皮生长因子家族中与胚泡着床胚泡着床障碍模型小鼠的着床率和胚泡着床位点 密切相关的因子,与问质细胞中EGFR相结合促进数,其机制可能与其促进种植窗期相关因子的表达 子宫内膜间质细胞的蜕膜化,可为胚泡着床作准 备[2]。本研究观察了补肾安胎方对胚泡着床...
Recombinant Rat HB-EGF与表皮生长因子受( epidermal growth factor receptor, EGFR/ErbBl)和ErbB4结合,激活下游信号通路,促进细胞增殖,抑制细胞凋亡,促进ECM合成。 Recombinant Rat HB-EGF参与组织损伤的早期修复反应,与多种器官纤维化密切相关。研究发现对胰腺纤维化及心脏纤维化均有促进作用。研究团队发现,活化的HSCs...
Eicosanoids and HB-EGF/EGFR in cancer 来自 国家科技图书文献中心 喜欢 0 阅读量: 19 作者:CC Yang,KW Chang 摘要: Heparin binding epidermal growth factor-like growth factor (HB-EGF) is involved in development and homeostasis as well as in pathological processing of chronic diseases, especially ...