阴道微生态失衡目的探讨宫颈高危型人乳头瘤病毒(HPV)感染患者血清肝素结合性表皮生长因子(HB-EGF),表皮生长因子受体(EGFR)表达水平以及患者阴道微生态失衡情况.方法选取2020年4月至2022年5月于河北省石家庄市人民医院就诊的169例宫颈炎患者作为研究对象,根据患者是否感染高危型HPV分为实验组(感染高危型HPV)88例,对照...
HB-EGF is an EGFR ligand and therefore can activate the RAS-MAPK pathway.31,32 We evaluated the expression levels of all seven EGFR ligands. Importantly, HB-EGF showed a strong and specific activation upon cancer cell - CAF co-culture (Figure 4A). Moreover, HB-EGF expression strongly ...
To confirm the role of the endothelial-derivedHbegf–Egfrsignalling pathway in beta cell proliferation, we assessed the beta cell proliferation rate response to HBEGF incubation. In MIN6 cells, HBEGF treatment significantly increased the expression of MKI67, cell viability and the proportion of EdU...
All ECD mutations however, showed strong activation towards all EGFR ligands, including the low affinity ligands (40%-80% of EGF stimulation). The constitutively active, ligand independent EGFRvIII mutation did not respond to any of the... P French,MD Wit,ID Heer,... - Neuro-Oncology 被引...
Cheng-ChiehInstituteYangInstituteKuo-WeiInstituteChangInstituteSpringerCancer & Metastasis ReviewsYang CC and Chang KW: Eicosanoids and HB‑EGF/EGFR in cancer. Cancer Metastasis Rev: 23 Jun, 2018 (Epub ahead of print).
目的 观察中药补肾安胎方对胚泡着床障碍模型小鼠胚泡着床情况及对类肝素结合样表皮生长因子(HB-EGF)及其受体(EGFR)表达的影响.方法 将妊娠雌鼠随机分为正常组,模型组,中药组,每组30只.分别于妊娠第5,6天(Pd5,6)用伊文思蓝尾静脉注射后取妊娠子宫.观察妊娠第5天(Pd5)各组对伊文思...
TMOD-11HBEGF ACTIVATES EGFR AND AXL TO FORM MALIGNANT GLIOMAS IN THE CONTEXT OF Ink4a/Arf AND Pten LOSSdoi:10.1093/neuonc/nov237.11Shin CliffordHolmen SheriNeuro-Oncology
Combination of hb-egf binding protein and egfr inhibitorThe present application relates to the combined use of an antigen-binding protein that binds HB-EGF and an EGFR tyrosine kinase inhibitor in medical treatment.U Pharma Gmbh
The combination of HB-EGF binding protein and EGFR inhibitorsThis application of the antigen binding proteins and EGFR tyrosine kinase inhibitor that binds to HB-EGF, regarding the combination of drug therapy.ツヴィック ウォルシュ エッシャー...
The PRISM predictions for a) EREG (blue) – EGFR (pink), b) EREG (blue) – ERBB4 (green) interaction, c) HBEGF (purple) - EGFR (pink) interacrion and d) HBEGF (purple) – ERBB4 (green) interacti...