Amphiregulin (AREG); epidermal growth factor receptor 1 (EGFR1; HER1; ErbB1); transforming growth factor-β1 (TGFB1)In vitro and mouse studies suggest inhibiting AREG-EGFR1 signaling could help treat idiopathic pulmonary fibrosis (IPF).
对幽门螺杆菌阳性和阴性胃粘膜增殖细胞核抗原(PCNA)转化生长因子α(TGF-α)表皮生长因子受体(EGFR)表达进行对比分析,结果表明HP阳性胃粘膜PCNA,TGF-α,EGFR的表达显著高于HP阴性胃粘膜(P〈0.05),且在不典型增生时达高峰,结果提示HP感染的胃粘膜处于高增殖状态,粘膜高增殖状态可能与TGF-α/EGFR过量表达有关,这也是...