Mouse having mutations including (i) a mutation in both alleles of protein kinase, DNA-activated, catalytic polypeptide (Prkdc) gene, (ii) a mutation in both alleles of the gene encoding for the interleukin-2 receptor (IL-2)-gamma -chain, (iii) a mutation in at least one allele of the...
PCR analysis of gene pyramids for the presence target allele(s) (cropped gels displayed). 1. DNA amplification ofGm1alleles using the primer RM444. 2. DNA amplification ofGm4alleles using the primer RM547. 3. DNA amplification ofSub1allele using the primer SUB1BC2. 4. DNA amplification of...
The term “homozygous” indicates that identical alleles reside at the same loci on homologous chromosomes. In contrast, “heterozygous” indicates that different alleles reside at the same loci on homologous chromosomes. A transgenic animal may be homozygous or heterozygous for a transgene. The term...
Mouse having mutations including (i) a mutation in both alleles of protein kinase, DNA-activated, catalytic polypeptide (Prkdc) gene, (ii) a mutation in both alleles of the gene encoding for the interleukin-2 receptor (IL-2)-gamma -chain, (iii) a mutation in at least one allele of the...
2.A kit for the early identification of fat deposition in bovines, wherein said kit comprises:(i) primers for amplifying a portion of a DDEF1 gene sequence, comprising a first primer molecule comprising the nucleotide sequence of SEQ ID NO: 1, a second primer molecule comprising the nucleot...
identical and in the sme relative positions and there should be a number, i.e. at least two and preferably at least three amino acids, at corresponding positions, which are not identical but have similar reactivities. In general there should be fewer than 20 numerical percent of amino acids ...
Allele. An “allele” is any of one or more alternative form of a gene, all of which relate to one trait or characteristic. In a diploid cell or organism, the two alleles of a given gene occupy corresponding loci on a pair of homologous chromosomes. Amplicon. A piece of DNA formed as...
1. Method for diagnosing a person having multiple sclerosis (MS) or being at risk of developing MS, comprising the following steps: - detecting the presence or absence of wild type SCF-Apoptosis-Response Gene- (wt-SARG-1-) protein and/or nucleic acids encoding wt-SARG-1 in a sample of ...
Thus, the 20S core is identical at its two ends. The x-ray structure of the archaebacterial proteasome has recently been resolved and was shown to contain a narrow pore in each α ring, and a large central cavity formed by the β rings. Accordingly, the central cavity is not exposed ...
Steck et al., “Identification af a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers,” Nat Genet 15, 356-62 (1997). Stein et al., “P13-kinzase inhibition: a target for drug development?”, Molecular Medicine Today, vol. 6,...